Project/scholarship details
- Project/scholarship ID
127675
- Reference
FCT-ANR/NEU-OSD/0258/2012
- FundRef URI
- Funder
FCT - Fundação para a Ciência e a Tecnologia, I.P.
- Funder's country
Portugal
- Funding program
3599-PPCDT
- Funding amount
159,843.00 €
- Start date
2013-05-02
- End date
2016-12-31
Documents
Construction of functional brain connectivity networks
Magalhães, Ricardo José Silva; Marques, Paulo César Gonçalves; Veloso, Telma Alves; Soares, José Miguel Montenegro; Sousa, Nuno; Alves, VictorGraph theory and the study of complex networks have, over the last decade, received increasing attention from the neuroscience research community. It allows for the description of the brain as a full network of connections, a connectome, as well as for the quantitative characterization of its topological properties. Still, there is a clear lack of standard procedures for building these networks. In this work we...
The bounds of education in the human brain connectome
Marques, Paulo César Gonçalves; Soares, José Miguel Montenegro; Magalhaes, Ricardo José da Silva; Santos, Nadine Correia; Sousa, NunoInter-individual heterogeneity is evident in aging; education level is known to contribute for this heterogeneity. Using a cross-sectional study design and network inference applied to resting-state fMRI data, we show that aging was associated with decreased functional connectivity in a large cortical network. On the other hand, education level, as measured by years of formal education, produced an opposite eff...
A framework for the automation of multimodalbrain connectivity analyses
Marques, Paulo César Gonçalves; Soares, José Miguel Montenegro; Magalhães, Ricardo José Silva; Sousa, Nuno; Alves, VictorIn neuroscience research, there has been an increasing interest in multimodal analysis, combining the strengths of unimodal analysis while reducing some of its drawbacks. However, this increases complexity in data processing and analysis, requiring a big amount of technical knowledge in image manipulation and a lot of iterative processes requiring user intervention. In this work we present a framework that inco...
Central autonomic nervous system response to autonomic challenges is altered in...
Pereira, Vitor H.; Marques, Paulo César Gonçalves; Magalhães, Ricardo José Silva; Português, João; Calvo, Lucy; Cerqueira, João José; Sousa, NunoAims: Takotsubo cardiomyopathy is an intriguing disease characterized by acute transient left ventricular dysfunction usually triggered by an episode of severe stress. The excessive levels of catecholamines and the overactivation of the sympathetic system are believed to be the main pathophysiologic mechanisms of Takotsubo cardiomyopathy, but it is unclear whether there is a structural or functional signature o...
A Hitchhiker's guide to functional magnetic resonance imaging
Soares, José Miguel Montenegro; Magalhães, Ricardo José Silva; Moreira, Pedro Miguel Silva; Sousa, Alexandre; Ganz, Edward; Sampaio, AdrianaFunctional Magnetic Resonance Imaging (fMRI) studies have become increasingly popular both with clinicians and researchers as they are capable of providing unique insights into brain functions. However, multiple technical considerations (ranging from specifics of paradigm design to imaging artifacts, complex protocol definition, and multitude of processing and methods of analysis, as well as intrinsic methodolo...
White matter changes in microstructure associated with a maladaptive response t...
Magalhães, R.; Bourgin, J.; Boumezbeur, F.; Marques, P.; Bottlaender, M.; Poupon, C.; Djemaï, B.; Duchesnay, E.; Mériaux, S.; Sousa, Nuno; Jay, T. M.In today's society, every individual is subjected to stressful stimuli with different intensities and duration. This exposure can be a key trigger in several mental illnesses greatly affecting one's quality of life. Yet not all subjects respond equally to the same stimulus and some are able to better adapt to them delaying the onset of its negative consequences. The neural specificities of this adaptation can b...
How age, sex and genotype shape the stress response
Novais, Ashley Cruz; Monteiro, Susana; Roque, Susana; Neves, Margarida Correia; Sousa, NunoExposure to chronic stress is a leading pre-disposing factor for several neuropsychiatric disorders as it often leads to maladaptive responses. The response to stressful events is heterogeneous, underpinning a wide spectrum of distinct changes amongst stress-exposed individuals'. Several factors can underlie a different perception to stressors and the setting of distinct coping strategies that will lead to indi...
An imaging characterization of the adaptive and maladaptive response to chronic...
Magalhães, Ricardo José da SilvaTese de doutoramento em Ciências da Saúde; Stress is a constant presence in the daily life of all beings and one’s ability to adapt to challenging circumstances has a real impact in the chance of survival. The response to stressful stimuli is regulated primarily by the hypothalamic-pituitary-adrenal (HPA) axis, but several other areas of the brain as well as hormonal circuits are known to be involved. The chron...
The dynamics of stress: a longitudinal MRI study of rat brain structure and con...
Magalhães, Ricardo José Silva; Barrière, D. A.; Novais, Ashley Cruz; Marques, Fernanda; Marques, Paulo César Gonçalves; Cerqueira, João JoséStress is a well-established trigger for a number of neuropsychiatric disorders, as it alters both structure and function of several brain regions and its networks. Herein, we conduct a longitudinal neuroimaging study to assess how a chronic unpredictable stress protocol impacts the structure of the rat brain and its functional connectome in both high and low responders to stress. Our results reveal the changes...
Brain semantic segmentation: a deep learning approach in human and Rat MRI studies
Rodrigues, Mariana FontainhasDissertação de mestrado em Biomedical Engineering Dissertation (área de especialização em Field of Medical informatics); Magnetic Resonance Imaging (MRI) provides information about anatomy and pathology. This type of technique is the most popular used for the study of rat and human brain. Classifying voxels according to the presence of relevant anatomic features is an important step in the pre-processing of the...
Report
Embed
<script type="text/javascript">
<!--
document.write('<div id="rcaap-widget"></div>');
document.write('<script type="text/javascript" src="https://www.rcaap.pt/snippet?resource=documents&project=FCT%2F3599-PPCDT%2F127675&fields=id,titles,creators,issueDate,link,descriptions"></script>');
-->
</script>