Project/scholarship details

  • Funder

    FCT - Fundação para a Ciência e a Tecnologia, I.P.

  • Funder's country

    Portugal

  • Funding program

    5876-PPCDTI

  • Funding amount

    183,696.00 €

  • Start date

    2010-04-01

  • End date

    2013-08-31

Documents

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Assessment of bone healing ability of calcium phosphate cements loaded with pla...

Babo, P. S.; Carvalho, P. P.; Santo, Vítor Sérgio Soares Espírito; Faria, Susana; Gomes, Manuela E.; Reis, R. L.

Injectable calcium phosphate cements have been used as a valid alternative to autologous bone grafts for bone augmentation with the additional advantage of enabling minimally invasive implantation procedures and for perfectly fitting the tissue defect. Nevertheless, they have low biodegradability and lack adequate biochemical signaling to promote bone healing and remodeling. In previous in vitro studies, we ob...

Date: 2016   |   Origin: RepositóriUM - Universidade do Minho
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Development of an injectable calcium Phosphate/Hyaluronic acid microparticles s...

Babo, Pedro Miguel Sousa; Santo, Vítor Sérgio Soares Espírito; Gomes, Manuela E.; Reis, R. L.

Despite the biocompatibility and osteoinductive properties of calcium phosphate (CaP) cements their low biodegradability hampers full bone regeneration. Herein the incorporation of CaP cement with hyaluronic acid (HAc) microparticles loaded with platelet lysate (PL) to improve the degradability and biological performance of the cements is proposed. Cement formulations incorporating increasing weight ratios of e...

Date: 2016   |   Origin: RepositóriUM - Universidade do Minho
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Engineering enriched microenvironments with gradients of platelet lysate in hyd...

Santo, Vítor Sérgio Soares Espírito; Babo, Pedro Miguel Sousa; Amador, Miguel; Correia, Cláudia; Cunha, Bárbara; Coutinho, Daniela F.; Neves, N. M.

Gradients of physical and chemical cues are characteristic of specific tissue microenvironments and contribute toward morphogenesis and tissue regeneration upon injury. Recent advances on microfluidics and hydrogel manipulation raised the possibility of generating biomimetic biomaterials enriched with bioactive factors and encapsulating cells following designs specifically tailored for a target application. The...

Date: 2016   |   Origin: RepositóriUM - Universidade do Minho
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The role of a platelet Lysate-Based compartmentalized system as a carrier of ce...

Babo, Pedro Miguel Sousa; Xinjie Cai; Plachokova, A.; Reis, R. L.; Jansen, John A.; Gomes, Manuela E.; Walboomers, X. Frank

Currently available clinical therapies are not capable to regenerate tissues that are lost by periodontitis. Tissue engineering can be applied as a strategy to regenerate reliably the tissues and function of damaged periodontium. A prerequisite for this regeneration is the colonization of the defect with the adequate cell populations. In this study, we proposed a bilayered system composed of (1) a platelet lysa...

Date: 2016   |   Origin: RepositóriUM - Universidade do Minho
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Production and characterization of hyaluronic acid microparticles for the contr...

Babo, P. S.; Reis, R. L.; Gomes, Manuela E.

Hyaluronic acid is the main polysaccharide present in the connective tissue. Besides its structural function as backbone of the extracellular matrix, hyaluronic acid plays staple roles in several biological processes including the modulation of inflammation and wound healing processes. The application of hyaluronic acid in regenerative medicine, either as cells and/or drug/growth factors delivery vehicles, reli...

Date: 2016   |   Origin: RepositóriUM - Universidade do Minho
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Evaluation of a platelet lysate bilayered system for periodontal regeneration i...

Babo, Pedro Miguel Sousa; Xinjie Cai; Plachokova, A.; Reis, R. L.; Jansen, John A.; Gomes, Manuela E.; Walboomers, X. Frank

With currently available therapies, full regeneration of lost periodontal tissues after periodontitis cannot be achieved. In this study, a combined compartmentalized system was tested, composed of (a) a platelet lysate (PL)-based construct, which was placed along the root aiming to regenerate the root cementum and periodontal ligament, and (b) a calcium phosphate cement composite incorporated with hyaluronic ac...

Date: 2018   |   Origin: RepositóriUM - Universidade do Minho
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