Project/scholarship details
- Project/scholarship ID
104347
- Reference
PTDC/SAU-FCF/104347/2008
- FundRef URI
- Funder
FCT - Fundação para a Ciência e a Tecnologia, I.P.
- Funder's country
Portugal
- Funding program
5876-PPCDTI
- Funding amount
119,711.00 €
- Start date
2010-04-01
- End date
2013-06-30
Documents
Monocarboxylate transporters: new molecular targets for colorectal carcinoma
Amorim, Ricardo; Martins, Sandra; Pereira, Helena Paula Fernandes; Pinheiro, Céline; Reis, R. L.; Longatto Filho, Adhemar; Preto, Ana; Baltazar, Fátima[Excerpt] Colorectal carcinoma (CRC) is the second leading cause of cancer-related death in industrialized countries1. 5-Fluorouracil (5-FU) is one of the most efficient chemotherapeutic agents in the treatment of CRC although resistance to 5-FU treatment has been reported2. CRC relies mostly on glycolysis to meet their energetic demands and, as a consequence, CRC cells produce large amounts of lactate that mus...
GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prog...
Pinheiro, Céline; Sousa, Bárbara; Albergaria, André; Paredes, Joana; Dufloth, Rozany; Vieira, Daniella; Schmitt, Fernando C.; Baltazar, FátimaWe thank Dr. Vitor Carneiro (pathologist from the Hospital do Divino Espírito Santo, Ponta Delgada, São Miguel, Azores), for his help in retrieving the breast cancer samples for this study.; The goal of the present work was to evaluate the correlation of glucose transporter 1 (GLUT1) and carbonic anhydrase IX (CAIX) with the monocarboxylate transporters 1 (MCT1) and 4 (MCT4) and their chaperone, CD147, in breas...
Zeolites: promising candidates for drug delivery systems (DDSs)
Vilaça, Natália; Amorim, Ricardo; Baltazar, Fátima; Fonseca, António Manuel; Neves, Isabel C.[Excerpt] The aim of controlled drug delivery systems (DDSs) is to administer the necessary amount of drug safely and effectively to specific sites in the human body and to regulate the temporal drug profile for maximum therapeutic benefits.[1] Zeolites are crystalline aluminosilicates solids with very regular microporous structures and they have been recently considered for medical use due to their biological ...
The basal epithelial marker P-cadherin associates with breast cancer cell popul...
Sousa, Bárbara; Ribeiro, Ana Sofia; Nobre, Ana Rita; Lopes, Nair; Martins, Diana; Pinheiro, Céline; Vieira, André Filipe; Albergaria, André"BMC Cancer 2014 14:734"; BACKGROUND: Cancer stem cells are hypoxia-resistant and present a preponderant glycolytic metabolism. These characteristics are also found in basal-like breast carcinomas (BLBC), which show increased expression of cancer stem cell markers.Recently, we demonstrated that P-cadherin, a biomarker of BLBC and a poor prognostic factor in this disease, mediates stem-like properties and resist...
Differential sensitivities to lactate transport inhibitors of breast cancer cel...
Santos, Filipa Morais; Gonçalves, Vera M.; Pinheiro, Sílvia; Vieira, André Filipe; Paredes, Joana; Schmitt, Fernando C.; Baltazar, FátimaThis is linked to the online version of the paper at: http://dx.doi.org/10.1530/ERC-13-0132.; The tumour microenvironment is known to be acidic due to high glycolytic rates of tumour cells. Monocarboxylate transporters (MCTs) play a role in extracellular acidification, which is widely known to be involved in tumour progression. Recently, we have described the upregulation of MCT1 in breast carcinomas and its as...
Targeting lactate transport suppresses in vivo breast tumour growth.
Moreira, António Herculano Jesus; Pinheiro, Céline; Baltazar, Fátima; Vilaça, João L.; Longatto Filho, Adhemar; Santos, Luísa Filipa Morais dosBACKGROUND Most cancers, including breast cancer, have high rates of glucose consumption, associated with lactate production, a process referred as "Warburg effect". Acidification of the tumour microenvironment by lactate extrusion, performed by lactate transporters (MCTs), is associated with higher cell proliferation, migration, invasion, angiogenesis and increased cell survival. Previously, we have described ...
Monocarboxylate transport inhibition potentiates the cytotoxic effect of 5-fluo...
Amorim, Ricardo; Pinheiro, Céline; Gonçalves, Vera Mónica Miranda; Pereira, Helena; Moyer, Mary P.; Preto, Ana; Baltazar, FátimaCancer cells rely mostly on glycolysis to meet their energetic demands, producing large amounts of lactate that are extruded to the tumour microenvironment by monocarboxylate transporters (MCTs). The role of MCTs in the survival of colorectal cancer (CRC) cells is scarce and poorly understood. In this study, we aimed to better understand this issue and exploit these transporters as novel therapeutic targets alo...
Significance of glycolytic metabolism-related protein expression in colorectal ...
Martins, Sandra; Amorim, Ricardo Luís Agra de; Pereira, Marta Sofia Carvalho Ribeiro Viana; Pinheiro, Céline; Silva, Patrícia; Couto, Carla; Alves, SaraBackground: Colorectal cancer (CRC) is one of the most common malignancies and a leading cause of cancer death worldwide. Most cancer cells display high rates of glycolysis with production of lactic acid, which is then exported to the microenvironment by monocarboxylate transporters (MCTs). The main aim of this study was to evaluate the significance of MCT expression in a comprehensive series of primary CRC cas...
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