Project/scholarship details
- Project/scholarship ID
105180
- Reference
PTDC/SAU-NEU/105180/2008
- FundRef URI
- Funder
FCT - Fundação para a Ciência e a Tecnologia, I.P.
- Funder's country
Portugal
- Funding program
5876-PPCDTI
- Funding amount
120,000.00 €
- Start date
2010-03-01
- End date
2013-02-28
Documents
Brain barriers and the acute-phase response
Marques, Fernanda; Correia-Neves, M; Sousa, João Carlos; Sousa, Nuno; Palha, Joana Almeida[Excerpt] Recent findings on the brain response to peripheral inflammation have broadened our knowledge on the acute phase response. Notably, such advances may lead to the characterization of acute phase proteins in body fluids other than the blood. Among these, and of particular interest, is the cerebrospinal fluid (CSF) that fills the brain ventricles, the subarachnoid space and the spinal cord. Acute phase r...
Interplay between depressive-like behavior and the immune system in an animal m...
Roque, Susana; Oliveira, Tiago Gil; Nóbrega, Cláudia; Silva, Palmira Conceição Araújo Barreira; Alves, Cláudio Nunes; Sousa, Nuno; Palha, Joana AlmeidaGlucocorticoids, namely dexamethasone, are prescribed during late gestation in pregnancies at risk of originating premature newborns, to promote fetal lung maturation. However, adverse early life events have been reported to induce long-lasting changes in the immune and central nervous systems. The accumulating evidence on bidirectional interactions between both systems in psychiatric disorders like depression,...
Immuno-Golgi as a tool for analyzing neuronal 3D-dendritic structure in phenoty...
Pinto, Luísa; Pinheiro, António Mateus; Morais, Mónica; Bessa, J. M.; Sousa, NunoCharacterization of neuronal dendritic structure in combination with the determination of specific neuronal phenotype or temporal generation is a challenging task. Here we present a novel method that combines bromodioxyuridine (BrdU) immunohistochemistry with Golgi-impregnation technique; with this simple noninvasive method, we are able to determine the tridimensional structure of dendritic arborization and spi...
Topographical analysis of the subependymal zone neurogenic niche
Falcão, Ana M.; Palha, Joana Almeida; Ferreira, Ana Catarina; Marques, Fernanda Cristina Gomes de Sousa; Sousa, Nuno; Sousa, João CarlosThe emerging model for the adult subependymal zone (SEZ) cell population indicates that neuronal diversity is not generated from a uniform pool of stem cells but rather from diverse and spatially confined stem cell populations. Hence, when analysing SEZ proliferation, the topography along the anterior-posterior and dorsal-ventral axes must be taken into account. However, to date, no studies have assessed SEZ pr...
Sustained remission from depressive-like behavior depends on hippocampal neurog...
Pinheiro, António Mateus; Pinto, Luísa; Bessa, J. M.; Morais, Mónica; Alves, N. D.; Monteiro, S.; Patrício, P.; Almeida, O. F. X.; Sousa, NunoImpairment of hippocampal neurogenesis has been associated with the expression of depressive-like symptoms and some studies have suggested neurogenesis as a critical factor in the normalization of behavior by antidepressant (AD) drugs. This study provides robust evidence that ongoing neurogenesis is essential for the maintenance of behavioral homeostasis and that its pharmacological arrest precipitates symptoms...
Stress-induced anhedonia is associated with hypertrophy of medium spiny neurons...
João, Bessa; Morais, Mónica; Marques, Fernanda; Pinto, Luísa; Palha, Joana Almeida; Sousa, NunoThere is accumulating evidence that the nucleus accumbens (NAc) has an important role in the pathophysiology of depression. As the NAc is a key component in the neural circuitry of reward, it has been hypothesized that anhedonia, a core symptom of depression, might be related to dysfunction of this brain region. Neuronal morphology and expression of plasticity-related molecules were examined in the NAc of rats ...
The behavioral and immunological impact of maternal separation: a matter of timing
Roque, Susana; Mesquita, Ana Raquel Marcelino; Palha, Joana Almeida; Sousa, Nuno; Neves, Margarida CorreiaMaternal separation (MS), an early life stressful event, has been demonstrated to trigger neuropsychiatric disorders later in life, in particular depression. Experiments using rodents subjected to MS protocols have been very informative for the establishment of this association. However, the mechanism by which MS leads to neuropsychiatric disorders is far from being understood. This is probably associated with ...
Report
Embed
<script type="text/javascript">
<!--
document.write('<div id="rcaap-widget"></div>');
document.write('<script type="text/javascript" src="https://www.rcaap.pt/snippet?resource=documents&project=FCT%2F5876-PPCDTI%2F105180&fields=id,titles,creators,issueDate,link,descriptions"></script>');
-->
</script>