Project/scholarship details
- Project/scholarship ID
105703
- Reference
PTDC/CTM/105703/2008
- FundRef URI
- Funder
FCT - Fundação para a Ciência e a Tecnologia, I.P.
- Funder's country
Portugal
- Funding program
5876-PPCDTI
- Funding amount
170,000.00 €
- Start date
2010-04-01
- End date
2013-09-30
Documents
De novo bone formation on macro/microporous silk and silk/nano-sized calcium ph...
Yan, Leping; Salgado, A. J.; Oliveira, Joaquim M.; Oliveira, A. L.; Reis, R. L.Macro/micro porous silk/nano-sized calcium phosphate scaffolds (SC16) with bioactive and superior physicochemical properties have been recently developed. In this study, we aim at evaluating the new bone formation ability of the SC 16 scaffolds in vivo, using silk fibroin scaffolds (S16) as control. The CaP distribution profile in the scaffolds was characterized by Micro-Computed Tomography. The in vitro minera...
Current concepts and challenges in osteochondral tissue engineering and regener...
Yan, Leping; Oliveira, Joaquim M.; Oliveira, Ana Leite; Reis, R. L."Publication Date (Web): February 20, 2015"; In the last few years, great progress has been made to validate tissue engineering strategies in preclinical studies and clinical trials on the regeneration of osteochondral defects. In the preclinical studies, one of the dominant strategies comprises the development of biomimetic/bioactive scaffolds, which are used alone or incorporated with growth factors and/or st...
Bilayered silk/silk-nanoCaP scaffolds for osteochondral tissue engineering: in ...
Yan, Leping; Silva-Correia, Joana; Oliveira, Mariana B.; Vilela, Carlos; Pereira, H.; Sousa, R. A.; Mano, J. F.; Oliveira, A. L.; Oliveira, Joaquim M.Novel porous bilayered scaffolds, fully integrating a silk fibroin (SF) layer and a silk-nano calcium phosphate (Silk-NanoCaP) layer for osteochondral defect (OCD) regeneration were developed. Homogeneous porosity distribution was achieved in the scaffolds, with calcium phosphate phase only retained in the Silk-NanoCaP layer. The scaffold presented compressive moduli of 0.4 MPa in wet state. Rabbit bone marrow ...
Finely tuned fiber-based porous structures for bone tissue engineering applicat...
Ribeiro, Viviana Pinto; Silva-Correia, Joana; Morais, Alain José Silva; Correlo, V. M.; Marques, A. P.; Ribeiro, A. S.; Silva, Carla; Durães, Nelson[Excerpt] Scaffolds developed for bone tissue engineering (TE) must possess specific structural properties to allow neo-tissue formation and integration within the material[1]. Several polymeric systems and processing methodologies have been proposed to develop bone TE scaffolds. Nevertheless, the so far proposed strategies do not fulfil all the requirements for effective bone regeneration. Textile technologies...
Tumor growth suppression induced by biomimetic silk fibroin hydrogels
Leping, Yan; Silva-Correia, Joana; Ribeiro, Viviana Pinto; Gonçalves, Vera Mónica Miranda; Correia, Cristina; Morais, Alain José Silva; Sousa, R. A.Protein-based hydrogels with distinct conformations which enable encapsulation or differentiation of cells are of great interest in 3D cancer research models. Conformational changes may cause macroscopic shifts in the hydrogels, allowing for its use as biosensors and drug carriers. In depth knowledge on how 3D conformational changes in proteins may affect cell fate and tumor formation is required. Thus, this st...
Core-shell silk hydrogels with spatially tuned conformations as drug delivery s...
Yan, Leping; Oliveira, J. M.; Oliveira, A. L.; Reis, R. L.Hydrogels of spatially controlled physicochemical properties are appealing platforms for tissue engineering and drug delivery. In this study, core-shell silk fibroin (SF) hydrogels of spatially controlled conformation were developed. The core-shell structure in the hydrogels was formed by means of soaking the preformed (enzymatically crosslinked) random coil SF hydrogels in methanol. When increasing the methano...
Silk-based anisotropical 3D biotextiles for bone regeneration
Ribeiro, Viviana Pinto; Silva-Correia, Joana; Nascimento, Ana I.; Morais, Alain José Silva; Marques, A. P.; Ribeiro, Ana S.; Silva, Carla J.Bone loss in the craniofacial complex can been treated using several conventional therapeutic strategies that face many obstacles and limitations. In this work, novel three-dimensional (3D) biotextile architectures were developed as a pos- sible strategy for flat bone regeneration applications. As a fully automated processing route, this strategy as potential to be easily industrialized. Silk fibroin (SF) yarns...
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