Project/scholarship details

  • Funder

    FCT - Fundação para a Ciência e a Tecnologia, I.P.

  • Funder's country

    Portugal

  • Funding program

    5876-PPCDTI

  • Funding amount

    120,000.00 €

  • Start date

    2010-06-14

  • End date

    2013-12-13

Documents

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Study of the dimorphic fungus Paracoccidioides brasiliensis: development of mol...

Barros, Diana Cláudia Martins Costa

Dissertação de mestrado em Genética Molecular; Paracoccidioides brasiliensis, a thermal dimorphic fungus, is the etiological agent of paracoccidioidomycosis, the most common systemic mycosis affecting the rural population of Latin America. During the last decade, molecular approaches have allowed a broader insight into P. brasiliensis. However, knowledge regarding fundamental biology of this fungus has been gre...

Date: 2010   |   Origin: RepositóriUM - Universidade do Minho
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Molecular biology of the dimorphic fungi Paracoccidioides SPP

Sturme, Mark H. J.; Puccia, Rosana; Goldman, Gustavo H.; Rodrigues, Fernando José dos Santos

Paracoccidioides spp, herein commonly referred as Paracoccidioides brasiliensis, is the etiological agent of racoccidioidomycosis (PCM), the most prevalent systemic mycosis endemic in Latin America. Many aspects of the biology of P. brasiliensis remain unknown, in particular its ecology and the apparent lack of a sexual reproduction stage in its life cycle. This review will highlight the current knowledge on th...

Date: 2011   |   Origin: RepositóriUM - Universidade do Minho
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Gene knockdown in Paracoccidioides brasiliensis using antisense RNA

Menino, João F.; Almeida, A. J.; Rodrigues, Fernando José dos Santos

Paracoccidioides brasiliensis is a thermal dimorphic fungus which at host environment exhibits a multinucleated and multibudding yeast form. The cellular and molecular mechanisms underlying these phenotypes remain to be clarified, mostly due to the absence of efficient classical genetic and molecular techniques. Here we describe a method for gene expression knockdown in P. brasiliensis by antisense RNA (aRNA) t...

Date: 2012   |   Origin: RepositóriUM - Universidade do Minho
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Functionality of the paracoccidioides mating α-pheromone-receptor system

Gomes, Jéssica Angélica Rezende; Alves, Ana G. Gomes; Menino, João F.; Coelho, Marco; Ludovico, Paula; Gonçalves, Paula; Sturme, Mark H. J.

Recent evidence suggests that Paracoccidioides species have the potential to undergo sexual reproduction, although no sexual cycle has been identified either in nature or under laboratory conditions. In the present work we detected low expression levels of the heterothallic MAT loci genes MAT1-1 and MAT1-2, the a-pheromone (PBa) gene, and the a- and apheromone receptor (PREB and PREA) genes in yeast and mycelia...

Date: 2012   |   Origin: RepositóriUM - Universidade do Minho
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Morphological heterogeneity of Paracoccidioides brasiliensis: relevance of the ...

Menino, João F.; Osório, Nuno S.; Sturme, Mark H. J.; Barros, Diana Cláudia Martins Costa; Alves, Ana G. Gomes; Almeida, A. J.; Costa, Patrício Soares

We thank Rosana Puccia for providing isolate Pb02.; Paracoccidioides brasiliensis budding pattern and polymorphic growth were previously shown to be closely linked to the expression of PbCDC42 and to infl uence the pathogenesis of the fungus. In this work we conducted a detailed morphogenetic evaluation of the yeast-forms of 11 different clinical and environmental P. brasiliensis isolates comprising four phylog...

Date: 2012   |   Origin: RepositóriUM - Universidade do Minho
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TLR9 activation dampens the early inflammatory response to paracoccidioides bra...

Menino, João Filipe; Saraiva, Margarida; Alves, Ana G. Gomes; Lobo-Silva, Diogo; Sturme, Mark H. J.; Gomes, Jéssica Angélica Rezende; Saraiva, Ana Laura

Background: Paracoccidioides brasiliensis causes paracoccidioidomycosis, one of the most prevalent systemic mycosis in Latin America. Thus, understanding the characteristics of the protective immune response to P. brasiliensis is of interest, as it may reveal targets for disease control. The initiation of the immune response relies on the activation of pattern recognition receptors, among which are TLRs. Both T...

Date: 2013   |   Origin: RepositóriUM - Universidade do Minho
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P. brasiliensis virulence is affected by SconC, the negative regulator of inorg...

Menino, João F.; Saraiva, Margarida; Gomes, Jéssica Angélica Rezende; Sturme, Mark H. J.; Pedrosa, Jorge; Castro, António G.; Ludovico, Paula

Conidia/mycelium-to-yeast transition of Paracoccidioidesbrasiliensis is a critical step for the establishment of paracoccidioidomycosis, a systemic mycosis endemic in Latin America. Thus, knowledge of the factors that mediate this transition is of major importance for the design of intervention strategies. So far, the only known pre-requisites for the accomplishment of the morphological transition are the tempe...

Date: 2013   |   Origin: RepositóriUM - Universidade do Minho
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