Project/scholarship details
- Project/scholarship ID
108557
- Reference
PTDC/SAU-NEU/108557/2008
- FundRef URI
- Funder
FCT - Fundação para a Ciência e a Tecnologia, I.P.
- Funder's country
Portugal
- Funding program
5876-PPCDTI
- Funding amount
56,835.00 €
- Start date
2010-03-19
- End date
2013-03-18
Documents
Effectiveness of the association between carbamazepine and peripheral analgesic...
Lemos, Laurinda; Fontes, Ramalho; Flores, Sara; Oliveira, Pedro; Almeida, ArmandoTreatment of trigeminal neuralgia (TN) is achieved by using adjuvant analgesics like antiepileptics, with carbamazepine (CBZ) being the first-line approach for TN patients, although side effects may be present. Other approaches using gabapentin, namely when associated with peripheral analgesic block of TN trigger points with the local anesthetic ropivacaine (ROP), resulted in decreased pain and daily drug intak...
Response properties of nociceptive neurons in the caudal ventrolateral medulla ...
Ribeiro, Filipa Pinto; Ansah, Osei B.; Almeida, Armando; Pertovaara, AnttiWe characterized response properties of neurons in the caudal ventrolateral medulla (CVLM), a structure involved in pain modulation. Electrophysiological recordings were performed in pentobarbitoneanesthetized control and monoarthritic rats. Noxious pinch, heat, cold and colorectal distension were used for peripheral test stimulation. To study central modulation of CVLM neurons and role in mediating descending ...
Risk factors for persistent postsurgical pain in women undergoing hysterectomy ...
Pinto, Patrícia; Mcintyre, Maria Teresa Pereira Coelho Mendonça; Silva, Cristina Nogueira; Almeida, Armando; Soares, Vera AraújoPersistent postsurgical pain (PPSP) is a major clinical problem with significant individual, social, and healthcare costs. The aim of this study was to examine the role of demographic, clinical and psychological risk factors in the development of persistent postsurgical pain (PPSP) after hysterectomy due to benign disorders. In a prospective study, a consecutive sample of 186 women was assessed 24 hours before ...
Differential effects of left/right neuropathy on rats’ anxiety and cognitive be...
Leite-Almeida, Hugo; Cerqueira, João; Wei, Hong; Ribeiro, Nuno Costa; Martins, Helena Anjos; Sousa, Nuno; Pertovaara, Antti; Almeida, ArmandoChronic pain is frequently accompanied by a deterioration of emotional behavior and cognitive function. A small number of studies in humans concluded that pain-associated negative affect is more pronounced when pain is localized in the left side of the body. It has been suggested that such side bias results from cortical function lateralization. It is not known, however, if other pain-associated behavioral chan...
Variable delay-to-signal: a fast paradigm for assessment of aspects of impulsiv...
Almeida, Hugo Leite; Melo, António; Pêgo, José M.; Bernardo, Sara; Milhazes, Nuno; Borges, Fernanda; Sousa, Nuno; Almeida, Armando; Cerqueira, JoãoTesting impulsive behavior in rodents is challenging and labor-intensive. We developed a new behavioral paradigm-the Variable Delay-to-Signal (VDS) test-that provides rapid and simultaneous assessment of response and decision impulsivity in rodents. Presentation of a light at variable delays signals the permission for action (nose poke) contingent with a reward. 2 blocks of 25 trials at 3 s delay flank a block ...
Risk factors for moderate and severe persistent pain in patients undergoing tot...
Pinto, Patrícia; McIntyre, Teresa; Ferrero, Ramón; Almeida, Armando; Araújo-Soares, VeraPersistent post-surgical pain (PPSP) is a major clinical problem with significant individual, social and health care costs. The aim of this study was to examine the joint role of demographic, clinical and psychological risk factors in the development of moderate and severe PPSP after Total Knee and Hip Arthroplasty (TKA and THA, respectively). This was a prospective study wherein a consecutive sample of 92 pati...
A role of supraspinal galanin in behavioural hyperalgesia in the rat
Amorim, Diana; Pereira, Ana David; Marques, Patrícia; Puga, Sónia Andreia Silva; Rebelo, Patrícia; Costa, Patrício Soares; Pertovaara, AnttiData from the manuscript: "A role of supraspinal galanin in behavioural hyperalgesia in the rat" – by Amorim et al, PLoS One. Available at: http://hdl.handle.net/1822/30584; INTRODUCTION: In chronic pain disorders, galanin (GAL) is able to either facilitate or inhibit nociception in the spinal cord but the contribution of supraspinal galanin to pain signalling is mostly unknown. The dorsomedial nucleus of the h...
Data from the manuscript [A role of supraspinal galanin in behavioural hyperalg...
Amorim, Diana; David-Pereira, Ana; Marques, Patrícia; Puga, Sónia Andreia Silva; Rebelo, Patrícia; Costa, Patrício Soares; Pertovaara, AnttiManuscript: "A role of supraspinal galanin in behavioural hyperalgesia in the rat" – by Amorim et al, PLoS One. Available at: http://hdl.handle.net/1822/32480; In chronic pain disorders, galanin (GAL) is able to either facilitate or inhibit nociception in the spinal cord but the contribution of supraspinal galanin to pain signalling is mostly unknown. The dorsomedial nucleus of the hypothalamus (DMH) is rich in...
Asymmetric c-fos expression in the ventral orbital cortex is associated with im...
Almeida, Hugo Leite; Guimarães, Marco Rafael; Cerqueira, João; Costa, Nuno Ribeiro; Martins, Helena Anjos; Sousa, Nuno; Almeida, ArmandoBACKGROUND: Recently we showed that unilateral peripheral neuropathic lesions impacted differentially on rat's emotional/cognitive behavior depending on its left/right location; importantly, this observation recapitulates clinical reports. The prefrontal cortex (PFC), a brain region morphofunctionally affected in chronic pain conditions, is involved in the modulation of both emotion and executive function and d...
Metabotropic glutamate 5 receptor in the infralimbic cortex contributes to desc...
Pereira, Ana Carla David; Puga, Sónia Andreia Silva; Gonçalves, S.; Amorim, Diana Alexandra Silva; Silva, Carmen L. O.; Pertovaara, A.; Almeida, ArmandoThe involvement of the prefrontal cortex in pain processing has been recently addressed. We studied the role of the infralimbic cortex (IL) and group I metabotropic glutamate receptors (mGluRs) in descending modulation of nociception in control and monoarthritic (ARTH) conditions. Nociception was assessed using heat-induced paw withdrawal while drugs were microinjected in the IL of rats. Local anesthesia of the...
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