Project/scholarship details
- Project/scholarship ID
113795
- Reference
PTDC/SAU-GMG/113795/2009
- FundRef URI
- Funder
FCT - Fundação para a Ciência e a Tecnologia, I.P.
- Funder's country
Portugal
- Funding program
5876-PPCDTI
- Funding amount
160,000.00 €
- Start date
2011-04-01
- End date
2014-09-30
Documents
Impact of TGF-ß1 -509C/T and 869T/C polymorphisms on glioma risk and patient pr...
Castro, Joana Vieira de; Gonçalves, Céline S.; Costa, Sandra; Linhares, Paulo; Vaz, Rui; Nabiço, Ricardo; Amorim, Júlia; Pereira, Marta VianaTransforming growth factor beta (TGF-ß) plays an important role in carcinogenesis. Two polymorphisms in the TGF-ß1 gene (-509C/T and 869T/C) were described to influence susceptibility to gastric and breast cancers. The 869T/C polymorphism was also associated with overall survival in breast cancer patients. In the present study, we investigated the relevance of these TGF-ß1 polymorphism in glioma risk and progno...
A transcriptomic signature mediated by HOXA9 promotes human glioblastoma initia...
Pojo, Marta; Gonçalves, Céline S.; Magalhães, Ana Xavier; Oliveira, Ana Isabel; Gonçalves, Tiago; Correia, Sara; Rodrigues, Ana JoãoGlioblastoma is the most malignant brain tumor, exhibiting remarkable resistance to treatment. Here we investigated the oncogenic potential of HOXA9 in gliomagenesis, the molecular and cellular mechanisms by which HOXA9 renders glioblastoma more aggressive, and how HOXA9 affects response to chemotherapy and survival. The prognostic value of HOXA9 in glioblastoma patients was validated in two large datasets from...
Effects of the functional HOTAIR rs920778 and rs12826786 genetic variants in gl...
Xavier-Magalhães, Ana; Oliveira, Ana Isabel Ferreira; de Castro, Joana Vieira; Pojo, Marta; Gonçalves, Céline S.; Lourenço, TatianaAbnormal expression of the long non-coding RNA HOX transcript antisense intergenic RNA (HOTAIR) is oncogenic in several human cancers, including gliomas. The HOTAIR single nucleotide polymorphisms (SNPs) rs920778 (C > T) and rs12826786 (C > T) present in the intronic enhancer and promoter regions of HOTAIR, respectively, are associated with expression, cancer susceptibility, and patient prognosis in some tumor ...
The impact of non-coding alterations in glioma: hints from HOTAIR and the TERT ...
Magalhães, Ana Xavier Silva deTese de doutoramento em Ciências da Saúde; Gliomas are the most common type of primary malignant brain tumor, and are a significant cause of cancer-associated morbidity and mortality. They are highly heterogeneous tumors, ranging from benign to highly malignant. Critically, attempts to develop curative therapies for high-grade gliomas have been unsuccessful thus far. Additionally, the etiology of glioma remains...
A semiautomated microfluidic platform for real-time investigation of nanopartic...
Carvalho, Mariana R.; Maia, F. Raquel; Silva-Correia, Joana; Costa, Bruno Marques; Reis, R. L.; Oliveira, J. M.Aims: develop a platform composed of labeled dendrimer nanoparticles and a microfluidic device for real-time monitoring of cancer cells fate. Materials and Methods: The physicochemical and biological characterization of the developed Carboxymethyl-chitosan/poly(amidoamine) (CMCht/PAMAM) dendrimer nanoparticles were performed using TEM, AFM, Zeta Sizer, DSC and cytotoxicity screening. Cancer cell lines derived f...
The long non-coding RNA HOTAIR is transcriptionally activated by HOXA9 and is a...
Xavier-Magalhães, Ana; Gonçalves, Céline S; Fogli, Anne; Lourenço, Tatiana; Pojo, Marta; Pereira, Bruno; Rocha, Miguel; Celeste Lopes, MariaThe lncRNA HOTAIR has been implicated in several human cancers. Here, we evaluated the molecular alterations and upstream regulatory mechanisms of HOTAIR in glioma, the most common primary brain tumors, and its clinical relevance. HOTAIR gene expression, methylation, copy-number and prognostic value were investigated in human gliomas integrating data from online datasets and our cohorts. High levels of HOTAIR w...
WNT6 is a novel oncogenic prognostic biomarker in human glioblastoma
Gonçalves, Céline S.; Castro, Joana Isabel Martins Cosme Vieira; Pojo, Marta; Martins, Eduarda P.; Queirós, Sandro Filipe Monteiro; Chautard, EmmanuelGlioblastoma (GBM) is a universally fatal brain cancer, for which novel therapies targeting specific underlying oncogenic events are urgently needed. While the WNT pathway has been shown to be frequently activated in GBM, constituting a potential therapeutic target, the relevance of WNT6, an activator of this pathway, remains unknown. Methods: WNT6 protein and mRNA levels were evaluated in GBM. WNT6 levels were...
Intercellular relationships in the tumor microenvironment: implications for can...
Oliveira, Ana Isabel FerreiraTese de Doutoramento em Envelhecimento e Doenças Crónicas; Cancer cells do not manifest the disease alone, but rather recruit and corrupt resident normal cell types to create the tumor microenvironment (TME). Collaborative interactions between neoplastic cancer cells and their supporting stroma leads to chronic proliferation and to the formation of organ-like structures that typify most human tumors. The TME pe...
Intracellular autofluorescence as a new biomarker for cancer stem cells in glio...
Castro, Joana Isabel Martins Cosme Vieira; Gonçalves, Celine Saraiva; Martins, Eduarda P.; Miranda-Lorenzo, Irene; Cerqueira, Mariana TeixeiraThe identification of cancer stem cells (CSCs), which are implicated in tumor initiation, progression, therapy resistance, and relapse, is of great biological and clinical relevance. In glioblastoma (GBM), this is still a challenge, as no single marker is able to universally identify populations of GBM cancer stem cells (GSCs). Indeed, there is still controversy on whether biomarker-expressing cells fulfill the...
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