Project/scholarship details

  • Funder

    FCT - Fundação para a Ciência e a Tecnologia, I.P.

  • Funder's country

    Portugal

  • Funding program

    5876-PPCDTI

  • Funding amount

    109,855.00 €

  • Start date

    2011-08-01

  • End date

    2015-01-31

Documents

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The advantages of Structural Equation Modelling to address the complexity of sp...

Moreira, Pedro Miguel Silva; Sotiropoulos, I.; Silva, Joana Margarida Gonçalves Mota; Takashima, Akihiko; Sousa, Nuno; Almeida, Hugo Leite

Background: Cognitive performance is a complex process influenced by multiple factors. Cognitive assessment in experimental animals is often based on longitudinal datasets analyzed using uni- and multi-variate analyses, that do not account for the temporal dimension of cognitive performance and also do not adequately quantify the relative contribution of individual factors onto the overall behavioral outcome. T...

Date: 2016   |   Origin: RepositóriUM - Universidade do Minho
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Chronic stress and glucocorticoids: from neuronal plasticity to neurodegeneration

Vyas, Sheela; Rodrigues, Ana João; Silva, Joana Margarida; Tronche, Francois; Almeida, Osborne F. X.; Sousa, Nuno; Sotiropoulos, I.

Stress and stress hormones, glucocorticoids (GCs), exert widespread actions in central nervous system, ranging from the regulation of gene transcription, cellular signaling, modulation of synaptic structure, and transmission and glial function to behavior. Their actions are mediated by glucocorticoid and mineralocorticoid receptors which are nuclear receptors/transcription factors. While GCs primarily act to ma...

Date: 2016   |   Origin: RepositóriUM - Universidade do Minho
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Absence of Tau triggers age-dependent sciatic nerve morphofunctional deficits a...

Lopes, Sofia Oliveira; Lopes, André Teixeira; Pinto, Vítor Manuel Silva; Guimarães, Marco Rafael; Sardinha, Vanessa Alexandra Morais; Silva, Sara Duarte

Dementia is the cardinal feature of Alzheimer's disease (AD), yet the clinical symptoms of this disorder also include a marked loss of motor function. Tau abnormal hyperphosphorylation and malfunction are well-established key events in AD neuropathology but the impact of the loss of normal Tau function in neuronal degeneration and subsequent behavioral deficits is still debated. While Tau reduction has been inc...

Date: 2016   |   Origin: RepositóriUM - Universidade do Minho
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Tau deletion prevents stress-induced dendritic atrophy in prefrontal cortex: ro...

Lopes, Sofia Oliveira; Teplytska, Larysa; Silva, João Luís Vaz Lima da; Dioli, Chrysoula; Trindade, Rita; Morais, Mónica; Webhofer, Christian

Tau protein in dendrites and synapses has been recently implicated in synaptic degeneration and neuronal malfunction. Chronic stress, awell-known inducer of neuronal/synaptic atrophy, triggers hyperphosphorylation of Tau protein and cognitive deficits. However, the cause–effect relationship between these events remains to be established. To test the involvement of Tau in stress-induced impairments of cognition,...

Date: 2017   |   Origin: RepositóriUM - Universidade do Minho
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Chronic stress triggers divergent dendritic alterations in immature neurons of ...

Dioli, Chrysoula; Patrício, Patrícia; Sousa, Nuno; Kokras, Nikolaos; Dalla, Christina; Guerreiro, Sara; Santos-Silva, Miguel A.; Rego, Ana Cristina

Chronic stress, a suggested precipitant of brain pathologies, such as depression and Alzheimer's disease, is known to impact on brain plasticity by causing neuronal remodeling as well as neurogenesis suppression in the adult hippocampus. Although many studies show that stressful conditions reduce the number of newborn neurons in the adult dentate gyrus (DG), little is known about whether and how stress impacts ...

Date: 2019   |   Origin: RepositóriUM - Universidade do Minho
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Dysregulation of autophagy and stress granule-related proteins in stress-driven...

Silva, Joana Margarida Gonçalves Mota; Rodrigues, Sara; Marques, Maria Belém Sousa Sampaio; Gomes, Patrícia; Carvalho, Andreia Alexandra Neves

Imbalance of neuronal proteostasis associated with misfolding and aggregation of Tau protein is a common neurodegenerative feature in Alzheimer's disease (AD) and other Tauopathies. Consistent with suggestions that lifetime stress may be an important AD precipitating factor, we previously reported that environmental stress and high glucocorticoid (GC) levels induce accumulation of aggregated Tau; however, the m...

Date: 2019   |   Origin: RepositóriUM - Universidade do Minho
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