Project/scholarship details
- Project/scholarship ID
114116
- Reference
PTDC/BIA-MIC/114116/2009
- FundRef URI
- Funder
FCT - Fundação para a Ciência e a Tecnologia, I.P.
- Funder's country
Portugal
- Funding program
5876-PPCDTI
- Funding amount
119,980.00 €
- Start date
2011-01-01
- End date
2014-06-30
Documents
Hypericum perforatum phenolics compounds: protective role in the toxicity induc...
Vieira, Pedro Miguel de Sousa; Marques, Belém Sampaio; Ludovico, Paula; Dias, Alberto Carlos PiresParkinson’s disease (PD) is a neurodegenerative disorder with high prevalence and is characterized by the loss of dopaminergic neurons and the presence of cytoplasmic eosinophilic inclusions named Lewy bodies, in which α-synuclein is the major constituent. Several studies implicate abnormal protein accumulation, protein phosphorylation, mitochondrial dysfunction and oxidative stress as common pathways implicate...
Evaluation of the protective effect of Hypericum perforatum phenolics compounds...
Vieira, Pedro Miguel de Sousa; Marques, Belém Sampaio; Ludovico, Paula; Dias, Alberto Carlos PiresParkinson’s disease (PD), first described by James Parkinson in 1817, is a chronic, progressive neurodegenerative disorder. The pathologic hallmark is a deterioration of the substantia nigra of yet unknown causes, resulting in a deficiency of dopamine, an important neurotransmitter for the basal ganglia circuit and the presence of cytoplasmic eosinophilic inclusions named Lewy bodies, in which α-synuclein is th...
The emerging role of autophagy/mitophagy in α-synuclein-induced toxicity: studi...
Marques, Belém SampaioTese de doutoramento em Ciências da Saúde; α-Synuclein (α-syn) misfolding and aggregation is strongly associated with both idiopathic and familial forms of Parkinson disease (PD). Evidence suggests that α-syn has an impact on cell clearance routes and protein quality control systems, such as the ubiquitin-proteasome system (UPS) and autophagy. Recent advances in the key role of the autosomal recessive PARK2/PAR...
The effects of anti-leukemia chemotherapy on LKB1-AMPK pathway functioning in a...
Pereira, Olga Marisa da SilvaDissertação de Mestrado em Ciências da Saúde; Acute myeloid leukemia (AML) is a clonal disorder characterized by genetic alterations in hematopoietic stem and/or progenitor cells, leading to the accumulation of leukemic myeloblasts. Current AML therapies rely mainly on high doses of cytarabine and doxorubicin, which promote good outcomes for young patients but that are highly toxic and have limited application ...
Involvement of yeast HSP90 isoforms in response to stress and cell death induce...
Silva, Maria Alexandra; Marques, Belém Sampaio; Fernandes, Ângela Margarida Oliveira; Carreto, Laura; Rodrigues, Fernando José dos SantosAcetic acid-induced apoptosis in yeast is accompanied by an impairment of the general protein synthesis machinery, yet paradoxically also by the up-regulation of the two isoforms of the heat shock protein 90 (HSP90) chaperone family, Hsc82p and Hsp82p. Herein, we show that impairment of cap-dependent translation initiation induced by acetic acid is caused by the phosphorylation and inactivation of eIF2 alpha by...
Reactive oxygen species, ageing and the hormesis police
Ludovico, Paula; Burhans, William C.For more than 50 years, the free radical theory served as the paradigm guiding most investigations of ageing. However, recent studies in a variety of organisms have identified conceptual and practical limitations to this theory. Some of these limitations are related to the recent discovery that caloric restriction and other experimental manipulations promote longevity by inducing hormesis effects in association...
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