Project/scholarship details
- Project/scholarship ID
115048
- Reference
PTDC/FIS/115048/2009
- FundRef URI
- Funder
FCT - Fundação para a Ciência e a Tecnologia, I.P.
- Funder's country
Portugal
- Funding program
5876-PPCDTI
- Funding amount
115,686.00 €
- Start date
2011-07-01
- End date
2014-10-31
Documents
Dextrin and conducting polymer containing biocomposites: properties and behavio...
Dias, B. Teixeira; del Valle, L. J.; Estrany, F.; Mano, J. F.; Reis, R. L.; Aleman, C.Both α-cyclodextrin and linear dextrin are used to prepare biocomposites with poly(3,4- ethylenedioxythiophene). Materials are prepared electrochemically in aqueous solution. Comparison with the pure polymer indicates that the electroactivity and electrostability decrease with the incorporation of the dextrins while the electrical conductivity is retained. The different properties of the two biocomposites sugge...
Shape memory chitosan-based scaffolds for biomedical applications
Correia, Ana Cristina OliveiraDissertação de mestrado integrado em Engenharia Biomédica (área de especialização em Biomateriais, Reabilitação e Biomecânica); The searching for materials that display mechanical properties able to satisfy the specifications required by their implantation aroused a great interesting in the context of shape memory materials. Shape memory polymers (SMPs) offer novel materials-based devices to solving scientific ...
Free and copolymerized gamma-cyclodextrins regulate performance of dexamethason...
Lima, A. C.; Puga, Ana M.; Mano, J. F.; Concheiro, Angel; Alvarez-Lorenzo, CarmenPolymeric particles acting as source of biological cues to promote tissue regeneration are currently an interesting topic in bone tissue engineering research. In this study, microspheres of dextran-methacrylated (dextran-MA) and γ-cyclodextrins (γ-CD) for the delivery of osteogenic agents were prepared by means of photopolymerization on biomimetic superhydrophobic surfaces. The effects of the incorporation of t...
Layer-by-layer assembly of light-responsive polymeric multilayer systems
Borges, J.; Rodrigues, L. C.; Reis, R. L.; Mano, J. F.Layer-by-Layer (LbL) assembly is a simple and highly versatile method tomodify surfaces and fabricate robust and highly-ordered nanostructured coatingsover almost any type of substrate. Such versatility enables the incorporationof a plethora of building blocks, including materials exhibiting switchableproperties, in a single device through a multitude of complementary intermolecularinteractions. Switchable mate...
Porous polylactic acid-silica hybrids: preparation, characterization, and study...
Pandis, C.; Trujillo, S.; Matos, Joana; Madeira, S.; Rodenas Rochina, Joaquín; Kripotou, S.; Kyritsis, A.; Mano, J. F.; Ribelles, J. L. GómezA novel approach to reinforce polymer porous membranes is presented. In the prepared hybrid materials, the inorganic phase of silica is synthesized in-situ and inside the pores of aminolyzed polylactic acid (PLA) membranes by sol-gel reactions using tetraethylorthosilicate (TEOS) and glycidoxypropyltrimethoxysilane (GPTMS) as precursors. The hybrid materials present a porous structure with a silica layer coveri...
Chitosan–alginate multilayered films with gradients of physicochemical cues
Silva, Joana M.; Caridade, S. G.; Oliveira, N. M.; Reis, R. L.; Mano, J. F.Tissues presenting continuous variations of properties in one direction have inspired the development of functional graded materials. In this work, we developed a new facile method for the development of continuous gradients in chitosan (CHIT) and alginate (ALG) polyelectrolyte multilayers (PEMs) obtained layer-by-layer based on the gradual dipping of CHIT/ALG coated glass slides in genipin solution. Stiffness ...
Unraveling the effect of the hydration level on the molecular mobility of nanol...
Borges, J.; Caridade, S. G.; Silva, Joana M.; Mano, J. F.This work investigates the influence of the hydration level on the molecular mobility and glass transition dynamics of free-standing chitosan/alginate (CHT/ALG) nanolayered systems. Non-conventional dynamic mechanical analysis identified two relaxation processes assigned to the α-relaxation of the two biopolymers, respectively CHT and ALG, when immersed in water/ethanol mixtures. This phenomenon explains the sh...
Polysaccharide-based freestanding multilayered membranes exhibiting reversible ...
Silva, Joana M.; Caridade, S. G.; Reis, R. L.; Mano, J. F.The design of self-standing multilayered structures based on biopolymers has been attracting increasing interest due to their potential in the biomedical field. However, their use has been limited due to their gel-like properties. Herein, we report the combination of covalent and ionic cross-linking, using natural and non-cytotoxic cross-linkers, such as genipin and calcium chloride (CaCl2). Combining both cros...
A closed chondromimetic environment within magnetic-responsive liquified capsul...
Correia, C. R.; Gil, S.; Reis, R. L.; Mano, J. F.TGF-β3 is enzymatically immobilized by transglutaminase-2 action to poly(l-lactic acid) microparticles coated with collagen II. Microparticles are then encapsulated with stem cells inside liquified spherical compartments enfolded with a permselective shell through layer-by-layer adsorption. Magnetic nanoparticles are electrostatically bound to the multilayered shell, conferring magnetic-response ability. The go...
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