Project/scholarship details
- Project/scholarship ID
119069
- Reference
PTDC/SAU-MIC/119069/2010
- FundRef URI
- Funder
FCT - Fundação para a Ciência e a Tecnologia, I.P.
- Funder's country
Portugal
- Funding program
5876-PPCDTI
- Funding amount
154,755.00 €
- Start date
2012-03-01
- End date
2015-08-31
Documents
How do Candida glabrata´s biofilms respond to antifungal drugs?
Rodrigues, Célia Fortuna; Rodrigues, E.; Silva, Sónia Carina; Azeredo, Joana; Henriques, MarianaCandida species are responsible for recurrent human infections, mostly in immunocompromised patients, due to their high vulnerability. Candida glabrata has been shown to have a major role in these infections being the second most prevalent species involved in human fungemia. Objective: To understand the effect of three different antifungal agents Fluconazole (Flu), Amphotericin B (AmB) and Caspofungin (Csf) - i...
Candida bracarensis: Evaluation of virulence factors and its tolerance to Ampho...
Moreira, A.; Silva, Sónia Carina; Botelho, C. M.; Sampaio, Paula; Pais, Célia; Henriques, MarianaCandida bracarensis is an uncommon Candida species found during an epidemiological study of candidiasis performed in Braga, Portugal. Initially, it was identified as C. glabrata, but recently detailed analyses pointed out their differences. So, little information is still available about C. bracarensis virulence factors and antifungal susceptibilities. Therefore, the main goal of this work is to evaluate the ab...
Fluconazole versus Voriconazole: Candida glabrata biofilms response to differen...
Rodrigues, Célia Fortuna; Gonçalves, Bruna; Rodrigues, E.; Silva, Sónia Carina; Azeredo, Joana; Henriques, MarianaCandida glabrata is the second most prevalent yeast in fungal infections, especially in immunocompromised and/or hospitalized patients. The azole resistance within this species is very well-known and results in a low therapeutic response of C. glabrata infections, particularly when associated with biofilms. Objective - To understand the different efficacies of two azoles against C. glabrata biofilms: - fluconaz...
Activity of phenolic compounds from plant origin against Candida species
Martins, Natália; Barros, Lillian; Henriques, Mariana; Silva, Sónia Carina; Ferreira, Isabel C. F. R.Candida albicans and other Candida species have been highly associated with several opportunistic fungal infections. Their ability to develop host infections is incited by different determinants, being virulence factors the most highlighted. Molecular targets of the antifungal drugs are crucial components for determination of yeast survival. Ergosterol, nucleic acids and glucan are the most studied molecular ta...
Plants used in folk medicine: the potential of their hydromethanolic extracts a...
Martins, Natália; Ferreira, Isabel C. F. R.; Barros, Lillian; Carvalho, Ana Maria; Henriques, Mariana; Silva, Sónia CarinaCurrently, opportunistic fungal infections are considered a serious problem regarding public health. Despite the advances towards the synthesis of new antifungal agents, an increasing incidence of drug-resistant microorganisms has been observed. In this sense, other alternatives are necessary. In the present work, the antifungal activity of extracts from ten different plants, commonly used in folk medicine, wer...
Novel strategies to fight Candida species infection
Rodrigues, E.; Silva, Sónia Carina; Azeredo, Joana; Henriques, MarianaIn recent years, there has been a significant increase in the incidence of human fungal infections. The increase in cases of infection caused by Candida species, and the consequent excessive use of antimicrobials, has favored the emergence of resistance to conventional antifungal agents over the past decades. Consequently, Candida infections morbidity and mortality are also increasing. Therefore, new approaches...
Candida glabrata biofilms: How far have we come?
Rodrigues, Célia Fortuna; Rodrigues, Maria Elisa Costa; Silva, Sónia Carina; Henriques, MarianaInfections caused by Candida species have been increasing in the last decades and can result in local or systemic infections, with high morbidity and mortality. After Candida albicans, Candida glabrata is one of the most prevalent pathogenic fungi in humans. In addition to the high antifungal drugs resistance and inability to form hyphae or secret hydrolases, C. glabrata retain many virulence factors that contr...
Susceptibility testing of Candida albicans and Candida glabrata to Glycyrrhiza ...
Martins, Natália; Costa-Oliveira, Sofia; Melo, Luís D. R.; Ferreira, Isabel C. F. R.; Azeredo, Joana; Henriques, Mariana; Silva, Sónia CarinaMedicinal plants and their botanical formulations have gained a pivotal attention among scientific researchers mainly due to its action as health promoters. Licorice (Glycyrrhiza glabra L.) constitutes a great example, with an increasingly evidenced antimicrobial potential. Opportunistic yeast infections constitute an alarming public health problem, highly exacerbated by the inefficacy of antifungal drugs and t...
The effectiveness of voriconazole in therapy of Candida glabratas biofilms oral...
Rodrigues, Célia F.; Gonçalves, Bruna; Rodrigues, M. Elisa; Silva, Sónia Carina; Azeredo, Joana; Henriques, MarianaCandida glabrata is one of most prevalente yeast in fungal infections, especially in immunocompromised patients. Its azole resistance results in a low therapeutic response, particularly when associated with biofilms. The main goal of this work was to study the effectiveness of voriconazole (Vcz) against C. glabrata biofilms oral pathologies, as esophageal or oropharyngeal candidiasis. Antifungal susceptibilitie...
Oral mucositis caused by Candida glabrata biofilms: failure of the concomitant ...
Rodrigues, Célia F.; Henriques, MarianaObjectives: Candida glabrata is becoming one of the most prevalent pathogenic yeasts in cases of oral diseases. Mucositis is an recurrent oral infection in immunocompromised patients, and the actual guidelines recommend the use of fluconazole (Flu) for many cases. However, the azole resistance by C. glabrata is renowned, causing a reduced therapeutic response, especially when it occurs in biofilms. In this stud...
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