Project/scholarship details
- Project/scholarship ID
120334
- Reference
PTDC/EBB-EBI/120334/2010
- FundRef URI
- Funder
FCT - Fundação para a Ciência e a Tecnologia, I.P.
- Funder's country
Portugal
- Funding program
5876-PPCDTI
- Funding amount
104,000.00 €
- Start date
2012-04-01
- End date
2015-07-31
Documents
Study of the fluorescence signal for gastrointestinal dysplasia detection
Pimenta, S.; Castanheira, Elisabete M. S.; Minas, GraçaThe detection of cancer at the dysplasia stage is one of the most important goals in biomedical research. Optical techniques, specifically diffuse reflectance and intrinsic fluorescence, may improve the ability to detect gastrointestinal (GI) cancers, since they have exquisite sensitivity to some intrinsic biomarkers present on the tissues. This work follows the research that has been done towards the implement...
Pressure sensor for gastrointestinal intraluminal measuring
Silva, Luís Rebelo; Sousa, Paulo J.; Gonçalves, L. M.; Minas, GraçaThis paper reports an innovative technique to measure intraluminal pressure in the gastrointestinal tract (GI), which is typically performed through an exam called oesophageal manometry. This type of measurement is performed with a catheter, comprising several pressure sensors along it, and gives important information for the diagnosis of motility and peristalsis disorders in the GI tract. The presented work ex...
Effect of β-PVDF Piezoelectric Transducers’ positioning on the acoustic streami...
Catarino, Susana Oliveira; Miranda, J. M.; Minas, GraçaThis paper reports the numerical and experimental analysis of the acoustic streaming effect in a fluidic domain. The actuation of a piezoelectric transducer generates acoustic waves that propagate to the fluids, generating pressure gradients that induce the flow. The number and positioning of the transducers affect the pressure gradients and, consequently, the resultant flow profile. Two actuation conditions we...
Optimized SU-8 processing for low-cost microstructures fabrication without clea...
Pinto, V. C.; Sousa, Paulo J.; Cardoso, Vanessa Fernandes; Minas, GraçaThe study and optimization of epoxy-based negative photoresist (SU-8) microstructures through a low-cost process and without the need for cleanroom facility is presented in this paper. It is demonstrated that the Ultraviolet Rays (UV) exposure equipment, commonly used in the Printed Circuit Board (PCB) industry, can replace the more expensive and less available equipment, as the Mask Aligner that has been used ...
Design and fabrication of SiO2/TiO2 and MgO/TiO2 based high selective optical f...
Pimenta, Sara; Cardoso, S.; Miranda, A.; De Beule, P.; Castanheira, Elisabete M. S.; Minas, GraçaThis paper presents the design, optimization and fabrication of 16 MgO/TiO2 and SiO2/TiO2 based high selective narrow bandpass optical filters. Their performance to extract diffuse reflectance and fluorescence signals from gastrointestinal tissue phantoms was successfully evaluated. The obtained results prove their feasibility to correctly extract those spectroscopic signals, through a Spearman’s rank correlati...
Characterization of silicon photodiodes for diffuse reflectance signal extraction
Pimenta, Sara; Carmo, João Paulo Pereira; Correia, R. G.; Minas, Graça; Castanheira, Elisabete M. S.Early detection of gastrointestinal (GI) can cers is one of most important concerns in medical field. Its detection at the earliest stage is crucial to increase the patient survival chances. Optical signals extraction and analysis, specifically diffuse reflectance and intrinsic fluorescence, may impr ove the ability to detect GI dysplasia, once some morphological and biochemical changes on the tissues (related ...
PDMS biofunctionalization study for the development of a microfluidic device: A...
Pinto, Vânia Cristina Gonçalves; Minas, Graça; Neves, Margarida CorreiaThe authors acknowledge to Sofia Neves from ICVS for her help in the antibodies selection.; This paper presents the study of the PDMS (poly(dimethylsiloxane)) surface functionalization for the development of a microfluidic immunosensor that quantitatively analyss salivary cortisol by optical detection. The functionalization was performed using different antibodies immobilization methods on PDMS surface: (a) imm...
Optical microsystem for analysis of diffuse reflectance and fluorescence signal...
Pimenta, Sara; Castanheira, Elisabete M. S.; Minas, GraçaThe detection of cancer at its earliest stage is crucial in order to increase the probability of a successful treatment. Optical techniques, specifically diffuse reflectance and fluorescence, may considerably improve the ability to detect pre-cancerous lesions. These techniques have high sensitivity to some biomarkers present on the tissues, providing morphological and biochemical information of normal and dise...
Characterization of silicon photodiodes for diffuse reflectance signal extraction
Pimenta, Sara; Carmo, João Paulo Pereira; Correia, Ramiro Gomes; Minas, Graça; Castanheira, Elisabete M. S.Early detection of gastrointestinal (GI) cancers is one of most important concerns in medical field. Its detection at the earliest stage is crucial to increase the patient survival chances. Optical signals extraction and analysis, specifically diffuse reflectance and intrinsic fluorescence, may improve the ability to detect GI dysplasia, once some morphological and biochemical changes on the tissues (related wi...
Design, fabrication and characterization of SiO2/TiO2 and MgO/TiO2 based high s...
Pimenta, Sara; Cardoso, S.; Castanheira, Elisabete M. S.; Minas, GraçaSpectroscopic techniques, specifically diffuse reflectance and fluorescence, can considerably improve the ability to detect Gastrointestinal (GI) dysplasia, since they have exquisite sensitivity to the cancer biomarkers present on the tissues. Therefore, the development of a spectroscopic microsystem on a chip will have a high clinical value, since it could be integrated with the conventional endoscopes and col...
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