Project/scholarship details
- Project/scholarship ID
121491
- Reference
PTDC/EQU-EPR/121491/2010
- FundRef URI
- Funder
FCT - Fundação para a Ciência e a Tecnologia, I.P.
- Funder's country
Portugal
- Funding program
5876-PPCDTI
- Funding amount
95,239.00 €
- Start date
2012-02-01
- End date
2015-01-31
Documents
Design and functionalization of chitin-based microspheres scaffolds
Silva, Simone Santos; Duarte, Ana Rita C.; Mano, J. F.; Reis, R. L.Chitin agglomerated scaffolds were produced and functionalized using green chemistry principles and clean technologies. This combination enabled the functionalization of chitin microparticles prepared by dissolution of the polymer in ionic liquids, followed by the application of a sol–gel method. Finally, the 3D constructs were moulded and dried by a supercritical assisted agglomeration method. Structural and m...
Supercritical fluid processing of natural based polymers doped with ionic liquids
Martins, M.; Craveiro, R.; Paiva, Alexandre; Duarte, Ana Rita C.; Reis, R. L.Some approaches have been developed in our group to investigate the role of ionic liquids as process and property modifiers of natural-based polymers. In our previous work, we proposed the use of ionic liquids as plasticizing agents for the creation of porous structures from a semi-crystalline natural-based polymer. The current work intended to complement the previous studies, evaluating the ability of ionic li...
Starch-based polymer-IL composites formed by compression moulding and supercrit...
Craveiro, R.; Martins, M.; Santos, G. B.; Correia, N.; Dionísio, M.; Barreiros, S.; Duarte, Ana Rita C.; Reis, R. L.; Paiva, AlexandreIn this work, blend of starch and poly-e-caprolactone (PCL) doped with different concentrations of 1-butyl-3-methylimidazolium acetate ([BMIM]Ac) or 1-butyl-3-methylimidazolium chloride ([BMIM]Cl) was studied. The blends were characterized by mechanical analysis, infra-red spectroscopy (FTIR), differential scanning calorimetry (DSC) and dielectric relaxation spectroscopy (DRS), evaluating the IL doping effect. ...
Enhanced performance of supercritical fluid foaming of natural-based polymers b...
Martins, Marta; Aroso, Ivo Manuel Ascensão; Reis, R. L.; Duarte, Ana Rita C.; Craveiro, R.; Paiva, AlexandreNatural deep eutetic solvents (NADES) are defined as a mixture of two or more solid or liquid components, which at a particular composition present a high melting point depression becoming liquids at room temperature. NADES are constituted by natural molecules and fully represent the green chemistry principles. For these reasons, the authors believe that the submit manuscript is a highly valuable contribution t...
Production of Poly(vinyl alcohol) (PVA) fibers with encapsulated natural deep e...
Mano, Francisca; Aroso, Ivo Manuel Ascensão; Barreiros, Susana; Borges, João Paulo; Reis, R. L.; Duarte, Ana Rita C.; Paiva, AlexandreFunctionalized electrospun fibers are of great interest for biomedical applications such as in the design of drug delivery systems. Nevertheless, in some cases the molecules of interest have poor solubility in water or have high melting temperatures. These drawbacks can be overcome using deep eutectic solvents. In this work, poly(vinyl alcohol) (PVA), a common biodegradable biopolymer, was used to produce new f...
Design of controlled release systems for THEDES - therapeutic deep eutectic sol...
Aroso, Ivo Manuel Ascensão; Craveiro, Rita; Rocha, Ângelo; Dionisio, Madalena; Barreiros, Susana; Reis, R. L.; Paiva, Alexandre; Duarte, Ana Rita C.Deep eutectic solvents (DES) can be formed by bioactive compounds or pharmaceutical ingredients. A therapeutic DES (THEDES) based on ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), and menthol was synthesized and its thermal behavior was analyzed by differential scanning calorimetry (DSC). A controlled drug delivery system was developed by impregnating a starch:poly-ϵ-caprolactone polymeric blend (SP...
Novel non-cytotoxic alginate–lignin hybrid aerogels as scaffolds for tissue eng...
Quraishi, Sakeena; Martins, Marta; Barros, Alexandre A.; Gurikov, Pavel; Raman, S. P.; Smirnova, Irina; Duarte, Ana Rita C.; Reis, R. L.uncorrected proof; This paper presents a novel approach towards the production of hybrid alginate-lignin aerogels. The key idea of the approach is to employ pressurized carbon dioxide for gelation. Exposure of alginate and lignin solution containing calcium carbonate to CO2 at 4.5 MPa resulted in a hydrogel formation. Various lignin and CaCO3 concentrations were studied. Stable hydrogels can be formed up to 2:1...
Fabrication and characterization of Eri silk fibers-based sponges for biomedica...
Silva, Simone Santos; Oliveira, Nuno M.; Oliveira, Mariana Braga; Costa, Diana Soares da; Naskar, Deboki; Mano, J. F.; Kundu, S. C.; Reis, R. L.Cocoon-derived semi-domesticated Eri silk fibers still lack exploitation for tissue engineering applications due to their poor solubility using conventional methods. The present work explores the ability to process cocoon fibers of non-mulberry Eri silk (Samia/Philosamia ricini) into sponges through a green approach using ionic liquid (IL) â 1-buthyl-imidazolium acetate as a solvent. The formation of β-sheet s...
Properties and thermal behavior of natural deep eutectic solvents
Craveiro, R.; Aroso, Ivo Manuel Ascensão; Flammia, V.; Carvalho, T.; Viciosa, M. T.; Dionísio, M.; Barreiros, S.; Reis, R. L.; Duarte, Ana Rita C.Natural deep eutectic solvents (NADES) have shown to be promising sustainable media for a wide range of applications. Nonetheless, very limited data is available on the properties of these solvents. A more comprehensive body of data on NADES is required for a deeper understanding of these solvents at molecular level, which will undoubtedly foster the development of new applications. NADES based on choline chlor...
Production of electrospun fast-dissolving drug delivery systems with therapeuti...
Mano, Francisca; Martins, Marta; Nogueira, Isabel Sá; Barreiros, Susana; Borges, João Paulo; Reis, R. L.; Duarte, Ana Rita C.; Paiva, AlexandreFast-dissolving delivery systems (FDDS) have received increasing attention in the last years. Oral drug delivery is still the preferred route for the administration of pharmaceutical ingredients. Nevertheless, some patients, e.g. children or elderly people, have difficulties in swallowing solid tablets. In this work, gelatin membranes were produced by electrospinning, containing an encapsulated therapeutic deep...
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