Project/scholarship details
- Project/scholarship ID
69263
- Reference
PTDC/QUI/69263/2006
- FundRef URI
- Funder
FCT - Fundação para a Ciência e a Tecnologia, I.P.
- Funder's country
Portugal
- Funding program
5876-PPCDTI
- Funding amount
72,300.00 €
- Start date
2007-12-01
- End date
2010-12-31
Documents
Bioactive poly(L-lactic acid)-chitosan hybrid scaffolds
Mano, J. F.; Hungerford, Graham; Gómez Ribelles, José L.Poly(L-lactic acid)/Chitosan (PLLA/CHT) hybrid scaffolds were prepared by depositing CHT onto the pore walls in order to form a micro-structured low dense foam inside previously prepared PLLA scaffolds. The morphology and pore architecture of the scaffolds were evaluated by scanning electronic microscopy (SEM) and micro-computational tomography (micro-CT). The microstructure of the CHT fraction depends on its c...
Bio-inspired mineral growth on porous spherulitic textured poly(L-lactic acid)/...
Ghosh, Satyabrata; Reis, R. L.; Mano, J. F.It has been shown that texture can strongly influence the adhesion, orientation and proliferation of cells onto the surface of biomaterials. Additionally, it is possible to imprint micrometer level textures throughout the scaffolds by melt compounding PLLA/polyethylene oxide (PEO) blend, quenching followed by leaching of PEO in water. The objective of this work is to verify how the texture in 3D porous PLLA/Bio...
Controlling cell behavior through the design of polymer surfaces
Alves, N. M.; Pashkuleva, I.; Reis, R. L.; Mano, J. F.Polymers have gained a remarkable place in the biomedical fi eld as materials for the fabrication of various devices and for tissue engineering applications. The initial acceptance or rejection of an implantable device is dictated by the crosstalk of the material surface with the bioentities present in the physiological environment. Advances in microfabrication and nanotechnology offer new tools to investigate ...
Encapsulation of adipose-derived stem cells and transforming growth factor-beta...
Rocha, Pedro M.; Espírito Santo, Vítor; Gomes, Manuela E.; Reis, R. L.; Mano, J. F.Tissue engineering (TE) is an emerging field for the regeneration of damaged tissues. The combination of hydrogels with stem cells and growth factors (GFs) has become a promising approach to promote cartilage regeneration. In this study, carrageenan-based hydrogels were used to encapsulate both cells and transforming growth factor-b1 (TGF-b1). The ATDC5 cell line was encapsulated to determine the cytotoxicity a...
Preparation and characterization of bioactive glass nanoparticles prepared by s...
Luz, Gisela; Mano, J. F.Bioactive glass nanoparticles (BG-NPs), based on both ternary (SiO(2)-CaO-P(2)O(5)) and binary (SiO(2)-CaO) systems, were prepared via an optimized sol-gel method. The pH of preparation and the effect of heat treatment temperature were evaluated, as well as the effect of suppressing P in the bioactivity ability of the materials. The morphology and composition of the BG-NPs were studied using FTIR, XRD and SEM. ...
Biomineralization in chitosan/Bioglass® composite membranes under different dyn...
Caridade, S. G.; Merino, Esther G.; Alves, N. M.; Mano, J. F.Fundamental aspects of biomineralization may be important in order to understand and improve calcification onto the surface of biomaterials. The biomineralization process is mainly followed in vitro by assessing the evolution of the apatite layer that is formed upon immersion of the material in Simulated Body Fluid (SBF). In this work we propose an innovative methodology to monitor apatite deposition by looking...
Composite membranes made of chitosan and Bioglass®: monitorization of the miner...
Caridade, S. G.; Merino, Esther G.; Alves, N. M.; Mano, J. F.In the orthopedics field, one of the major hurdles that surgeons face on daily basis is the need for bone replacing materials to restore defects that lose capability for self repair. To date, autograft materials remain as the “gold standard” for bone repair; however donor-site morbidity and limitations on the amount of tissue that can be collected have led scientists to search for new materials capable to induc...
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