Project/scholarship details
- Project/scholarship ID
70063
- Reference
PTDC/QUI/70063/2006
- FundRef URI
- Funder
FCT - Fundação para a Ciência e a Tecnologia, I.P.
- Funder's country
Portugal
- Funding program
5876-PPCDTI
- Funding amount
150,600.00 €
- Start date
2008-01-01
- End date
2011-12-31
Documents
Gallium labeled NOTA-based conjugates for peptide receptor-mediated medical ima...
Sá, Arsénio Vasconcelos; Matias, Áurea A.; Prata, M. Isabel M.; Geraldes, Carlos F. G. C.; Ferreira, Paula M. T.; André, João P.We report a straightforward and efficient synthetic strategy for the synthesis of three model glycine-arginine-glycine-aspartic-glycine (GRGDG) conjugates based on derivatives of NOTA and of their Ga(III) complexes targeted to the integrin αѵβ₃receptor. 71Ga NMR spectroscopy showed that the Ga(III)-labeled conjugates are highly stable in aqueous solution. The 67Ga-labeled conjugates proved to have high kinetic ...
Triaza-based amphiphilic chelators : synthetic route, in vitro characterization...
Sá, Arsénio Vasconcelos; Prata, M. Isabel M.; Geraldes, Carlos F. G. C.; André, João P.Radiogalium chelates are important for diagnostic imaging in nuclear medicine (PET and ƴ-scintigraphy). Micelles are adequate colloidal vehicles for the delivery of therapeutic and diagnostic agents to organs and tissues. In this paper we describe the synthesis and in vitro and in vivo studies of a series of micelles-forming Ga(III) chelates targeted for the liver. The amphiphilic ligands are based on NOTA (NOT...
The interaction of La3+ complexes of DOTA/DTPA-glycoconjugates with the RCA120 ...
Teixeira, João M. C.; Dias, David M.; Cañada, Javier; Martins, J. A. R.; André, João P.; Jiménez-Barbero, Jesús; Geraldes, Carlos F. G. C.The study of ligand-receptor interactions using high resolution NMR techniques, namely the Saturation Transfer Difference (STD), is presented for the recognition process between La(III) complexes of DOTA mono(amide) and DTPA bis(amide) glycoconjugates and the galactose specific lectin Ricinus Communis agglutinin (RCA120). This new class of Gd(III)-based potential targeted MRI contrast agents (CAs), bearing one ...
Ga(III) chelates of amphiphilic DOTA-based ligands : synthetic route and in vit...
Fontes, André Filipe Gomes Soares; Prata, M. Isabel M.; Geraldes, Carlos F. G. C.; André, João P.In this work we report a synthetic strategy of amphiphilic DOTA-based chelators bearing a variable size α-alkyl chain at one of the pendant acetate arms (from six to fourteen carbon atoms), compatible with their covalent coupling to amine-bearing biomolecules. The amphiphilic behavior of the micelles-forming Ga(III) chelates (critical micelle concentration), their stability in blood serum and their lipophilicit...
Gold nanoparticles functionalised with stable, fast water exchanging Gd3+ chela...
Ferreira, Miguel Filipe Moreira Marques; Mousavi, Bibimaryam; Ferreira, Paula M. T.; Martins, Catarina; Helm, Lothar; Martins, José A.Gold nanoparticles functionalized with Gd3+ chelates displaying fast water exchange, superb pH stability and inertness towards transmetalation with Zn2+ have been prepared and characterized as a new high relaxivity (29 mM-1s-1, 30 MHz, 25 ºC) Contrast Agent potentially safe for in vivo MRI applications. The Lipari-Szabo treatment for internal rotation was used to evaluate the effect of linker flexibility on the...
Development of new high transparent hybrid organic-inorganic monoliths with sur...
Sandra, Moreira; Silva, Carlos J. R.; Prado, Luis A. S. A.; Costa, Manuel F. M.; Boev, Victor Ivanov; Martín-Sánchez, J.; Gomes, M. J. M.In this work, we report on the preparation and optical, thermal and morphological characterization of flexible and transparent hybrid gel materials by sol-gel process. The material synthesis was performed using two different derived siloxanes (3-isocyanate propyltriethoxysilane and 3-glycidoxypropyltrimethoxysilane) and two polyether chains with diamine terminal groups with different molecular weight. Xerogels ...
Amide conjugates of the DO3A-N-(alpha-amino)propionate ligand: leads for stable...
Ferreira, Miguel Filipe Moreira Marques; Martins, André F.; Martins, Catarina I. O.; Ferreira, Paula M. T.; Tóth, Éva; Rodrigues, Tiago B.A novel synthetic methodology for preparing amide conjugates of the DO3A-N-(alfa-amino)propionate chelator is described, using the synthesis of the DO3A-N-(alfa-benzoylamido)propionate chelator as an illustrative example. The model Gd(DO3A-N-(alfa-benzoylamido)propionate) chelate displays accelerated water exchange, stability in a wide pH range and inertness towards transmetallation by Zn2+. The Gd(DO3A-N-(alaf...
Ga[NO2A-N-(alfa-amino)propionate] chelates: synthesis and evaluation as potenti...
Ferreira, Miguel F.; Pereira, Goreti; André, João P.; Prata, M. I. M.; Ferreira, Paula M. T.; Martins, José A.; Geraldes, Carlos F. G. C.The availability of commercial 68Ge/68Ga cyclotron-independent 68Ga3+ generators is making Positron Emission Tomography (PET) accessible to most hospitals, which is generating a surge of interest in the design and synthesis of bi-functional chelators for Ga3+. In this work we introduce the NO2A-N-(alfa-amino)propionic acid family of chelators based on the triazacyclononane scaffold. Complexation of the parent N...
Optical and electrical behavior of organic/inorganic hybrid with embedded gold ...
Moreira, S.; Silva, J. P. B.; Silva, Carlos J. R.; Costa, M. F. M.; Gomes, M. J. M.Gold nanoparticles (AuNPs) with different diameters (from 4 up to 10 nm) were immobilized within a amine-alcohol-silicate matrix [AA(600)] by mixing a preformed Au nanoparticle colloidal solution with the precursors of amine-alcohol-silicate, prior to the sol–gel transition. The organic–inorganic hybrid (OIH) nanocomposites were synthetized by sol–gel method by reaction of amino-functionalized polyether and a s...
Ln[DO3A-N-alfa-(pyrenebutanamido)propionate] complexes : optimized relaxivity a...
Ferreira, Miguel F.; Pereira, Goreti; Martins, A. F.; Martins, Catarina I. O.; Prata, M. I. M.; Petoud, S.; Toth, E.; Ferreira, Paula M. T.We have proposed recently that the DO3A-N-alfa-(amino)propionate chelator and its amide conjugates are leads to targeted, high relaxivity, safe Contrast Agents for Magnetic Resonance Imaging. In this work we illustrate further the expeditious nature and robustness of the synthetic methodologies developed by preparing the DO3A-N-(alfa-pyrenebutanamido)propionate chelator. Its Gd3+ chelate retains the optimized w...
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