Project/scholarship details
- Project/scholarship ID
83290
- Reference
PIC/IC/83290/2007
- FundRef URI
- Funder
FCT - Fundação para a Ciência e a Tecnologia, I.P.
- Funder's country
Portugal
- Funding program
5876-PPCDTI
- Funding amount
160,000.00 €
- Start date
2009-03-01
- End date
2012-11-30
Documents
Williams Syndrome and memory: a neuroanatomic and cognitive approach
Sampaio, Adriana; Sousa, Nuno; Férnandez, Montse; Vasconcelos, Cristiana; Shenton, Martha E.; Gonçalves, Óscar F.Williams Syndrome (WS) is described as displaying a dissociation within memory systems. As the integrity of hippocampal formation (HF) is determinant for memory performance, we examined HF volumes and its association with memory measures in a group of WS and in a typically development group. A significantly reduced intracranial content was found in WS, despite no differences were observed for HF absolute volume...
Abnormal processing of emotional prosody in Williams syndrome: an event-related...
Pinheiro, Ana P.; Galdo-Álvarez, Santiago; Rauber, Andréia Schurt; Sampaio, Adriana; Niznikiewicz, Margaret; Gonçalves, Óscar F.Williams syndrome (WS), a neurodevelopmental genetic disorder due to a microdeletion in chromosome 7, is described as displaying an intriguing socio-cognitive phenotype. Deficits in prosody production and comprehension have been consistently reported in behavioral studies. It remains, however, to be clarified the neurobiological processes underlying prosody processing in WS. This study aimed at characterizing t...
Autobiographical narratives in Williams Syndrome: structural, process and conte...
Gonçalves, Óscar F.; Pinheiro, Ana P.; Sampaio, Adriana; Férnandez, Montse; Henriques, Margarida Rangel; Sousa, NunoWilliams syndrome (WS) is a neurodevelopmental disorder, with an intriguing cognitive phenotype. Previous studies found support for an atypical profile of fictional narrative production in WS (Gonçalves et al. The British Journal of Developmental Disabilities, 56(111), 89-109, 2010). This study aimed at testing if the same profile is observed when individuals with WS tell autobiographical narratives. Using a ne...
Is there evidence for cognitive intervention in Alzheimer disease? A systematic...
Alves, Jorge; Magalhaes, Rosana; Thomas, Roger E.; Gonçalves, Óscar F.; Petrosyan, Agavni; Sampaio, AdrianaSeveral studies have shown that cognitive intervention may be beneficial for people with Alzheimer disease (AD), but literature reviews conducted so far, have yielded mixed and inconclusive results. In this work, through an extensive bibliographic search, we aim: (1) to analyze the efficacy of cognitive intervention in patients diagnosed with AD; (2) to provide an estimate of the feasibility of cognitive interv...
Cognitive stimulation for portuguese older adults with cognitive impairment: a ...
Alves, Jorge; Costa, Filipa Alves; Magalhães, Rosana; Gonçalves, Óscar F.; Sampaio, AdrianaAlthough some studies point to cognitive stimulation as a beneficial therapy for older adults with cognitive impairments, this area of research and practice is still lacking dissemination and is underrepresented in many countries. Moreover, the comparative effects of different intervention durations remain to be established and, besides cognitive effects, pragmatic parameters, such as cost-effectiveness and exp...
Neurocognitive profile and cognitive intervention in Alzheimer's disease
Alves, Jorge Evandro de AraújoTese de Doutoramento em Psicologia (Especialidade de Psicologia Clínica); Cognitive and cerebral changes occur throughout normal and abnormal aging (namely dementia). Dementia represents major individual and societal burden with Alzheimer's disease (AD) being a leading cause. Advances in neuroimaging methods and neuropsychological assessment techniques have led to an improved characterization of healthy aging a...
Differential activation of the default mode network in jet lagged individuals
Coutinho, Joana; Gonçalves, Óscar F.; Maia, Liliana Filipa Costa; Vasconcelos, Cristiana Fernandes; Perrone-McGovern, Kristin; Simon-Dack, StephanieLong-term exposure to transmeridian flights has been shown to impact cognitive functioning. Nevertheless, the immediate effects of jet lag in the activation of specific brain networks have not been investigated. We analyzed the impact of short-term jet lag on the activation of the default mode network (DMN). A group of individuals who were on a transmeridian flight and a control group went through a functional ...
Cognitive rehabilitation in a visual variant of Alzheimer's disease
Alves, Jorge; Magalhães, Rosana; Arantes, Mavilde; Cruz, Sara; Gonçalves, Óscar F.; Sampaio, AdrianaAlzheimer's disease (AD) is commonly associated with marked memory deficits; however, nonamnestic variants have been consistently described as well. Posterior cortical atrophy (PCA) is a progressive degenerative condition in which posterior regions of the brain are predominantly affected, therefore resulting in a pattern of distinctive and marked visuospatial symptoms, such as apraxia, alexia, and spatial negle...
Default mode network dissociation in depressive and anxiety states
Coutinho, Joana Fernandes Pereira; Fernandes, Sara Catarina da Veiga; Soares, José Miguel Montenegro; Maia, Liliana Filipa Costa; Gonçalves, Óscar F.The resting state brain networks, particularly the Default Mode Network (DMN), have been found to be altered in several psychopathological conditions such as depression and anxiety. In this study we hypothesized that cortical areas of the DMN, particularly the anterior regions - medial prefrontal cortex and anterior cingulate cortex - would show an increased functional connectivity associated with both anxiety ...
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