Project/scholarship details
- Project/scholarship ID
99422
- Reference
PTDC/SAU-OSM/099422/2008
- FundRef URI
- Funder
FCT - Fundação para a Ciência e a Tecnologia, I.P.
- Funder's country
Portugal
- Funding program
5876-PPCDTI
- Funding amount
174,976.00 €
- Start date
2010-04-01
- End date
2013-03-31
Documents
Novel approach to create hybrid and hierarchical scaffolds aimed for tissue reg...
Oliveira, Sara M.; Silva, Tiago H.; Reis, R. L.; Mano, J. F.Tissue Engineering scaffolds with a wide range of properties and using several types of materials have been produced using different processing techniques. Among those, hybrid scaffolds, made of synthetic biodegradable and natural-origin polysaccharides, have been arising as the most adequate 3D structures to support the mechanical solicitations once implanted as well as cell adhesion, proliferation and differe...
Gellan gum : hydroxyapatite composite hydrogels for bone tissue engineering
Manda-Guiba, G. M.; Oliveira, Mariana B.; Mano, J. F.; Marques, A. P.; Oliveira, Joaquim M.; Correlo, V. M.; Reis, R. L.The modification of polymeric matrices by adding calcium-phosphate derivatives has been proven an effective strategy for tailoring the properties of scaffolds employed in bone tissue engineering. In this regard and, considering the biomechanics of bone as well as the durotactic response of osteoblasts, this study builds on the hypothesis that the preparation of novel Gellan Gum (GG)-Hydroxyapatite (HA) hydrogel...
Improved regeneration of mice full-thickness excisional wounds by human adipose...
Cerqueira, M. T.; Santos, T. C.; Pirraco, Rogério P.; Frias, A. M.; Martins, A. R.; Reis, R. L.; Marques, A. P.A totalidade dos resumos foram publicados em "J. Tissue Eng. Regen. Med. 2012; 6 (Suppl. 2) : 8–39."
Fish scales patterning guiding hASC growth
Silva, Joana M.; Afonso, David Losa de Areia; Silva, Tiago H.; Volpato, F.; Motta, A.; Marques, A. P.; Mano, J. F.; Reis, R. L.; Migliaresi, C.Marine organisms and materials exhibit interesting properties for their use in biomedical applications, following biomimetic approaches [1,2]. For instance, the white seabass (Lates Calcarifer) scales exhibit a very interesting pattern, which inspire their use as a guiding platform for cellular growth, in a tissue regeneration approach. Moreover, fish scales are composed of hydroxyapatite and type I collagen fi...
Perivascular-like cells contribute to the stability of the vascular network of ...
Mendes, L. F.; Pirraco, Rogério P.; Szymczyk, Wojciech; Frias, A. M.; Santos, T. C.; Reis, R. L.; Marques, A. P.In recent years several studies have been supporting the existence of a close relationship in terms of function and progeny between Mesenchymal Stem Cells (MSCs) and Pericytes. This concept has opened new perspectives for the application of MSCs in Tissue Engineering (TE), with special interest for the pre-vascularization of cell dense constructs. In this work, cell sheet technology was used to create a scaffol...
Human adipose stem cells cell sheet constructs impact epidermal morphogenesis i...
Cerqueira, M. T.; Pirraco, Rogério P.; Santos, T. C.; Rodrigues, D. B.; Frias, A. M.; Martins, A.; Reis, R. L.; Marques, A. P.Among the wide range of strategies to target skin repair/regeneration, tissue engineering (TE) with stem cells at the forefront, remains as the most promising route. Cell sheet (CS) engineering is herein proposed, taking advantage of particular cell-cell and cell-extracellular matrix (ECM) interactions and subsequent cellular milieu, to create 3D TE constructs to promote full-thickness skin wound regeneration. ...
Nanostructured multilayer compartments : towards multifunctionality and ‘‘cell-...
Costa, Rui R.; Castro, E.; Arias, F. J.; Rodríguez-Cabello, José Carlos; Mano, J. F.In living organisms, there are phenomena that require the presence of specific biomolecules with distinct function and in variable concentra- tions at a given time, such as the healing and regeneration of tissue and organ lesions. In this work, we propose the use of a compartment- ed drug delivery device for the multiple release of bioactive agents. It consists of nanostructured microcapsules confined within a ...
Dextran sulphate and ficcol fail as macromolecular crowders to enhance extracel...
Pirraco, Rogério; Carvalho, F.; Reis, R. L.; Marques, A. P.Publicado em "Journal of Tissue Engineering and Regenerative Medicine", vol. 7, supp. 1 (2013); The development of strategies based on the use of scaffolds for Tissue Engineering and Regenerative Medicine(TERM) has been hindered by the inability of researchers to present solutions to overcome problems mainly related with the biocompatibility of materials andin vivoperfusion of the 3D structures. It is in this c...
Human skin cell fractions fail to self-organize within a gellan gum/Hyaluronic ...
Cerqueira, M. T.; Silva, L. P. da; Santos, T. C.; Pirraco, Rogério; Correlo, V. M.; Marques, A. P.; Reis, R. L.Split-thickness autografts still are the current gold standard to treat skin, upon severe injuries. Nonetheless, autografts are dependent on donor site availability and often associated to poor quality neoskin. The generation of dermal–epidermal substitutes by tissue engineering is seen as a promising strategy to overcome this problematic. However, solutions that can be safely and conveniently transplanted in o...
Gellan gum-hyaluronic acid spongy-like hydrogels and cells from adipose tissue ...
Cerqueira, Mariana Teixeira; Silva, Lucília Pereira; Santos, Tírcia Carlos; Pirraco, Rogério P.; Correlo, V. M.; Reis, R. L.; Marques, Alexandra PintoCurrently available substitutes for skin wound healing often result in the formation of nonfunctional neotissue. Thus, urgent care is still needed to promote an effective and complete regeneration. To meet this need, we proposed the assembling of a construct that takes advantage of cell-adhesive gellan gum-hyaluronic acid (GG-HA) spongy-like hydrogels and a powerful cell-machinery obtained from adipose tissue, ...
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