Project/scholarship details

  • Funder

    FCT - Fundação para a Ciência e a Tecnologia, I.P.

  • Funder's country

    Portugal

  • Funding program

    POCI

  • Funding amount

    91,464.00 €

  • Start date

    2005-08-01

  • End date

    2008-07-31

Documents

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The choroid plexus response to peripheral inflammatory stimulus

Marques, Fernanda; Sousa, João Carlos; Correia-Neves, M; Oliveira, P.; Sousa, Nuno; Palha, Joana Almeida

Increased interest is being raised on the interaction between systemic inflammation and the brain. The choroid plexus (CP) constitutes a monolayer of epithelial cells located within the brain ventricles and is responsible for the production of cerebrospinal fluid (CSF). Despite the knowledge that the CP capillaries are fenestrated, allowing free passage of molecules and cells, the involvement of the vast blood-...

Date: 2007   |   Origin: RepositóriUM - Universidade do Minho
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The Adhesion GPCR GPR125 is specifically expressed in the choroid plexus and is...

Pickering, Chris; Hägglund, Maria; Szmydynger-Chodobska, Joanna; Marques, Fernanda; Palha, Joana Almeida; Waller, Linn; Chodobski, Adam

Background: GPR125 belongs to the family of Adhesion G protein-coupled receptors (GPCRs). A single copy of GPR125 was found in many vertebrate genomes. We also identified a Drosophila sequence, DmCG15744, which shares a common ancestor with the entire Group III of Adhesion GPCRs, and also contains Ig, LRR and HBD domains which were observed in mammalian GPR125.Results: We found specific expression of GPR125 in ...

Date: 2008   |   Origin: RepositóriUM - Universidade do Minho
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Kinetic profile of the transcriptome changes induced in the choroid plexus by p...

Marques, Fernanda; Sousa, João Carlos; Coppola, Giovanni; Falcão, Ana Luisa Mendanha; Rodrigues, Ana João; Geschwind, Daniel H.; Sousa, Nuno

The choroid plexus, being part of the blood-brain barriers and responsible for the production of cerebrospinal fluid, is ideally positioned to transmit signals into and out of the brain. This study, using microarray analysis, shows that the mouse choroid plexus displays an acute-phase response after an inflammatory stimulus induced in the periphery by lipopolysaccharide (LPS). Remarkably, the response is specif...

Date: 2009   |   Origin: RepositóriUM - Universidade do Minho
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Altered iron metabolism is part of the choroid plexus response to peripheral in...

Marques, Fernanda; Falcão, Ana M.; Sousa, João Carlos; Coppola, Giovanni; Geschwind, Daniel H.; Sousa, Nuno; Neves, Margarida Correia

Iron is essential for normal cellular homeostasis but in excess promotes free radical formation and is detrimental. Therefore, iron metabolism is tightly regulated. Here, we show that mechanisms regulating systemic iron metabolism may also control iron release into the brain at the blood-choroid plexus-cerebrospinal fluid (CSF) barrier. Intraperitoneal administration of lipopolysaccharide (LPS) in mice triggers...

Date: 2009   |   Origin: RepositóriUM - Universidade do Minho
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What have we learned from TTR-Null mice: novel functions for TTR?

Sousa, João Carlos; Palha, Joana Almeida

Ablation of the gene encoding for transthyretin (TTR) in mice showedthat, in the adult, TTR is not necessary for thyroid hormone and vitamin A deliveryto tissues despite the decreased levels of serum thyroxine and vitamin A. Surpris-ingly, the absence of TTR resulted in behavioral alterations. Specifically, TTR-nullmice display decreased signs of depressive-like behavior, increased exploratoryactivity, and impa...

Date: 2009   |   Origin: RepositóriUM - Universidade do Minho
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Brain barriers and the acute-phase response

Marques, Fernanda; Correia-Neves, M; Sousa, João Carlos; Sousa, Nuno; Palha, Joana Almeida

[Excerpt] Recent findings on the brain response to peripheral inflammation have broadened our knowledge on the acute phase response. Notably, such advances may lead to the characterization of acute phase proteins in body fluids other than the blood. Among these, and of particular interest, is the cerebrospinal fluid (CSF) that fills the brain ventricles, the subarachnoid space and the spinal cord. Acute phase r...

Date: 2011   |   Origin: RepositóriUM - Universidade do Minho
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