List of publications

New antitumor and antiangiogenic heterocyclic compounds: synthesis, molecular modeling, screening of enzymatic inhibition and studies in tumor and endothelial cell lines with tyrosine kinase membrane receptors as targets.


The current list of publications was generated automatically by the RCAAP portal on 2025-01-11. This list contains all the publications deposited in the repositories from the RCAAP network repositories to which was attributed the funding identifier: info:eu-repo/grantAgreement/FCT/5876-PPCDTI/111060.
This list is not updated automatically and refers only to the contents identified until the date of its generation. To fulfil with the obligations associated with the open rightsAccess policies from Fundação para a Ciência e a Tecnologia, please mention this link in the scientific reports required by this funding agency.

Project/scholarship information

 
Name of project/scholarship New antitumor and antiangiogenic heterocyclic compounds: synthesis, molecular modeling, screening of enzymatic inhibition and studies in tumor and endothelial cell lines with tyrosine kinase membrane receptors as targets.
Funder FCT - Fundação para a Ciência e a Tecnologia, I.P.
Funding program 5876-PPCDTI
Project/scholarship ID 111060
Reference PTDC/QUI-QUI/111060/2009
FundRef URI http://www.fct.pt/apoios/projectos/consulta/vglobal_projecto.phtml.en?idProjecto=111060&idElemConcurso=3703
Start date 2010-12-24
End date 2014-06-23
Funding amount 134,529.00 €
 

Report information

 

Summary

Report date 2025-01-11
Number of documents 14

Documents by repository

rum 14

Documents by document type

conference object 6
doctoral thesis 1
journal article 7

Documents by rightsAccess rights

restrictedAccess 1
openAccess 13

Documents

New di(hetero)arylethers and di(hetero)arylamines in the thieno[3,2-b]pyridine series: Synthesis, growth inhibitory activity on human tumor cell lines and non-tumor cells, effects on cell cycle and on programmed cell death Queiroz, Maria João R. P.; Peixoto, Daniela; Calhelha, Ricardo C.; Soares, Pedro; dos Santos, Tiago; Lima, Raquel T.; Campos, Joana F.; Abreu, Rui M. V.; Ferreira, Isabel C. F. R.; Vasconcelos, M. Helena Open Access Journal article 2013 rum http://hdl.handle.net/1822/63889
1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR2 tyrosine kinase inhibitors: synthesis, docking, studies, enzymatic and cellular assays Queiroz, Maria João R. P.; Peixoto, Daniela; Soares, Pedro; Abreu, Rui M. V.; Froufe, Hugo J. C.; Calhelha, Ricardo C.; Ferreira, Isabel C. F. R.; Costa, Raquel; Soares, Raquel Open Access Conference object 2012 rum http://hdl.handle.net/1822/22311
Synthesis of novel 1-Aryl-3-[2-,3- Or 4-(Thieno[3,2-b]Pyridin-7-Ylthio)Phenyl]Ureas and evaluation as VEGFR2 Tyrosine kinase inhibitors Peixoto, Daniela; Queiroz, Maria João R. P.; Abreu, Rui M. V.; Froufe, Hugo J. C.; Calhelha, Ricardo C.; Ferreira, Isabel C. F. R. Open Access Conference object 2012 rum http://hdl.handle.net/1822/22312
Synthesis of novel heterocyclic compounds based on rational design and evaluation of their antitumor and antiangiogenic potential in human endothelial and tumor cell lines with tyrosine kinase membrane receptors as targets Machado, Vera Alexandra Pereira Restricted Access Doctoral thesis 2016 rum http://hdl.handle.net/1822/44973
1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR2 inhibitors: synthesis, docking enzymatic and cellular assays Peixoto, Daniela; Calhelha, Ricardo C.; Soares, Pedro; Abreu, Rui M. V.; Froufe, Hugo J. C.; Ferreira, Isabel C. F. R.; Costa, Raquel; Soares, Raquel Open Access Conference object 2012 rum http://hdl.handle.net/1822/22433
Synthesis of Tetracyclic systems and (Thio)Ureas from Aminodi(Hetero)Arylamines in the Thieno[3,2-b]Pyridine series Queiroz, Maria João R. P.; Peixoto, Daniela; Calhelha, Ricardo C. Open Access Conference object 2012 rum http://hdl.handle.net/1822/22307
Synthesis and evaluation of tumor cell growth inhibition of Methyl 3-Amino-6-[(hetero)arylethynyl]thieno[3,2-b]pyridine-2-carboxylates: structure-activity relationships, effects on the cell cycle and apoptosis Queiroz, Maria João R. P.; Calhelha, Ricardo C.; Silva, Luís A. Vale; Pinto, Eugénia; Almeida, Gabriela M.; Vasconcelos, M. Helena Open Access Journal article 2011 rum http://hdl.handle.net/1822/14372
Synthesis of thienopyridine derivatives as potential antitumorals and/or antiangiogenics Begouin, Agathe; Peixoto, Daniela; Queiroz, Maria João R. P. Open Access Conference object 2013 rum http://hdl.handle.net/1822/22329
Antioxidant activity of aminodiarylamines in the thieno[3,2-b]pyridine series: radical scavenging activity, lipid peroxidation inhibition and redox profile Calhelha, Ricardo C.; Peixoto, Daniela; Vilas Boas, Miguel; Queiroz, Maria João R. P.; Ferreira, Isabel C. F. R. Open Access Journal article 2014 rum http://hdl.handle.net/1822/63897
Aminodi(hetero)arylamines in the thieno[3,2-b]pyridine series: synthesis, effects in human tumor cells growth, cell cycle analysis, apoptosis and evaluation of toxicity using non-tumor cells Calhelha, Ricardo C.; Ferreira, Isabel C. F. R.; Peixoto, Daniela; Abreu, Rui M. V.; Silva, L. A. Vale; Pinto, Eugénia; Lima, Raquel T.; Alvelos, Maria I.; Vasconcelos, M. Helena; Queiroz, Maria João R. P. Open Access Journal article 2012 rum http://hdl.handle.net/1822/22006
Fluorescence studies on new potential antitumoral 1,3-diarylurea derivatives in the thieno[3,2-b]pyridine series encapsulated in magnetoliposomes Rodrigues, Ana Rita O.; Mendes, Pedro M. F.; Castanheira, Elisabete M. S.; Coutinho, Paulo J. G.; Peixoto, Daniela; Queiroz, Maria João R. P. Open Access Conference object 2012 rum http://hdl.handle.net/1822/19954
Synthesis, antiangiogenesis evaluation and molecular docking studies of 1-Aryl-3-[(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas: Discovery of a new substitution pattern for type II VEGFR-2 Tyr kinase inhibitors Machado, Vera A.; Peixoto, D.; Costa, R.; Froufe, H. J. C.; Calhelha, Ricardo C.; Abreu, R. M. V; Ferreira, Isabel C. F. R.; Soares, R.; Queiroz, Maria João R. P. Open Access Journal article 2015 rum https://hdl.handle.net/1822/39853
Synthesis of 2-(hetero)arylthieno[2,3-b] or [3,2-b]pyridines from 2,3-dihalopyridines, (hetero)arylalkynes and Na2S. Further functionalizations Peixoto, Daniela; Begouin, Agathe; Queiroz, Maria João R. P. Open Access Journal article 2012 rum https://hdl.handle.net/1822/22010
Anti-hepatocellular carcinoma activity using human HepG2 cells and hepatotoxicity of 6-substituted methyl 3-aminothieno[3,2-b]pyridine-2-carboxylate derivatives: in vitro evaluation, cell cycle analysis and QSAR studies Abreu, Rui M. V.; Ferreira, Isabel C. F. R.; Calhelha, Ricardo C.; Lima, Raquel T.; Vasconcelos, M. Helena; Adega, Filomena; Chaves, Raquel; Queiroz, Maria João R. P. Open Access Journal article 2011 rum https://hdl.handle.net/1822/14341