1191 documents found, page 1 of 120
International consensus on natural orifice specimen extraction surgery (NOSES) ...
Guan, X; Liu, Z; Longo, A; Cai, JC; Tzu-Liang Chen, W; Chen, L; Chun, HK; Costa Pereira, JM; Efetov, S; Escalante, R; He, QS; Hu, JH; Kayaalp, CIn recent years, natural orifice specimen extraction surgery (NOSES) in the treatment of colorectal cancer has attracted widespread attention. The potential benefits of NOSES including reduction in postoperative pain and wound complications, less use of postoperative analgesic, faster recovery of bowel function, shorter length of hospital stay, better cosmetic and psychological effect have been described in col...
High frequency of CHD7 mutations in congenital hypogonadotropic hypogonadism
Gonçalves, CI; Patriarca, FM; Aragüés, JM; Carvalho, D; Fonseca, F; Martins, S; Marques, O; Pereira, BD; Martinez-de-Oliveira, J; Lemos, MCCongenital hypogonadotropic hypogonadism (CHH) is characterized by lack of normal pubertal development due to deficient gonadotropin-releasing hormone (GnRH) secretion or action, and is caused by genetic defects in several genes. Mutations in the CHD7 gene cause CHARGE syndrome (Coloboma of the eye, Heart defects, Atresia of the choanae, Retardation of growth and development, Genital hypoplasia and Ear abnormal...
Endoscopic Submucosal Dissection for the Treatment of Superficial Epithelial Ga...
Costa, RS; Ferreira, A; Leal, T; Costa, D; Rolanda, C; Gonçalves, RBACKGROUND: The emergence of endoscopic submucosal dissection (ESD) made possible en bloc resection of neoplastic gastric lesions, regardless of lesion size, with reduced rates of complications and recurrence. This technique has become the preferred method for curative resection, instead of conventional endoscopic mucosal resection and surgery, when distant metastases have negligible risk. In Western countries ...
Eosinophilic fasciitis: an atypical presentation of a rare disease
Cabral, C; Novais, A; Araujo, D; Mosca, A; Lages, A; Knock, AEosinophilic fasciitis, or Shulman's disease, is a rare disease of unknown etiology. It is characterized by peripheral eosinophilia, hypergammaglobulinemia, and high erythrocyte sedimentation rate. The diagnosis is confirmed by a deep biopsy of the skin. The first line of treatment is corticotherapy. We present a rare case of eosinophilic fasciitis in a 27-year-old woman with an atypical presentation with symme...
Magnetic resonance imaging of cerebellar cysts in a neonate with congenital cyt...
Quintas-Neves, M; Soares-Fernandes, JPCongenital cytomegalovirus infection is one of the most common congenital viral infections in the world. Brain magnetic resonance imaging plays a key role in evaluating brain involvement and establishing prognosis; several characteristic features have been described. We present a description of cerebellar cysts in a neonate with polymerase chain reaction-confirmed cytomegalovirus congenital infection, and discu...
Rational Identification of a Colorectal Cancer Targeting Peptide through Phage ...
Ferreira, D; Silva, AP; Nobrega, FL; Martins, IM; Barbosa-Matos, C; Granja, S; Martins, SF; Baltazar, F; Rodrigues, LRColorectal cancer is frequently diagnosed at an advanced stage due to the absence of early clinical indicators. Hence, the identification of new targeting molecules is crucial for an early detection and development of targeted therapies. This study aimed to identify and characterize novel peptides specific for the colorectal cancer cell line RKO using a phage-displayed peptide library. After four rounds of sele...
Accuracy of the new rapid test for monitoring adalimumab levels
Rocha, C; Afonso, J; Lago, P; Arroja, B; Vieira, AI; Dias, CC; Magro, FThe loss of response to adalimumab (ADL) has been related to low serum concentrations at trough. Currently, most methods commercially available for the quantification of ADL are enzyme-linked immunosorbent assay (ELISA) based, with a turnaround time of approximately 8 h, delaying the target dosage adjustment to the subsequent infusion. In this study, we aimed to evaluate the performance of the newly available r...
Characterization of a large cluster of HIV-1 A1 infections detected in Portugal...
Araújo, PM; Carvalho, A; Pingarilho, M; Abecasis, AB; Osório, NSHIV-1 subtypes associate with differences in transmission and disease progression. Thus, the existence of geographic hotspots of subtype diversity deepens the complexity of HIV-1/AIDS control. The already high subtype diversity in Portugal seems to be increasing due to infections with sub-subtype A1 virus. We performed phylogenetic analysis of 65 A1 sequences newly obtained from 14 Portuguese hospitals and 425 ...
Easy resolution of severe obstructive kidney injury
Cabral, C; Novais, AP; Araújo, D; Mosca, AChronic constipation is a common diagnosis with a high prevalence in the elderly. Constipation affects the quality of life of sick individuals, bringing several clinical complications.
Quality of life in elderly Portuguese war veterans with post-traumatic stress s...
Pereira, MG; Machado, JC; Pereira, M; Lopes, C; Pedras, SBACKGROUND: Studies show that post-traumatic stress symptoms among Portuguese veterans who participated in Colonial War (1961-75) are high, even though 43 years have gone by since the end of the war. AIMS: This study analyzed the role of family type, personality traits, and social support as predictors of post-traumatic stress symptoms and quality of life in war veterans, and whether satisfaction with social su...