Project/scholarship details
- Project/scholarship ID
46399
- Reference
POCTI/NSE/46399/2002
- FundRef URI
- Funder
FCT - Fundação para a Ciência e a Tecnologia, I.P.
- Funder's country
Portugal
- Funding program
POCI
- Funding amount
90,000.00 €
- Start date
2003-09-01
- End date
2006-08-31
Documents
Intraepithelial nerve fibers project into the lumen of the larynx
Rodrigues, Manuel Lima; Nunes, Rui; Almeida, ArmandoObjectives/Hypothesis: Studies on the morphology and location of the sensory receptors in the laryngeal mucosa have resulted in insufficient and sometimes conflicting data. In the present study the authors analyzed the distribution and morphology of sensory nerve plexuses and terminal fibers in the laryngeal mucosa of the rat. Study Design: Two groups of Male Wistar rats were used in this laboratory study; the ...
Distribution of neuromuscular junctions in laryngeal and syringeal muscles in v...
Rodrigues, Manuel Lima; Fernandes, Ana Valle; Nunes, Rui; Almeida, ArmandoVertebrates are capable of producing a variable sound spectrum. In mammals, lissamphibia, and reptiles, the larynx is the vocal organ responsible for sound production, whereas in birds it is produced by the syrinx, an avian organ located at the base of trachea. The distribution of neuromuscular junctions responsible for the fine control of laryngeal muscle (LM) and syringeal muscle (SM), although studied with s...
Descending inhibitory systems
Pertovaara, Antti; Almeida, ArmandoThe authors have been supported by the Academy of Finland (grant 78582), the Sigrid Jusélius Foundation, Finland, Grünenthal Foundation, Portugal and Project no POCTI/NSE/46399/2002 from FCT and FEDER, Portugal. The authors wish to thank Dr. Denis Artchakov for illustrations.
Medullary control of nociceptive transmission: reciprocal dual communication wi...
Almeida, Armando; Almeida, Hugo Leite; Tavares, IsauraControl of pain perception, essential for organism surviving and recovery from disease, is exerted by higher brain centers integrating nociception with emotional and cognitive information and modulating the brainstem-spinal feedback loops that regulate spinal nociceptive transmission. Development of chronic pain deregulates the forebrain-brainstem-spinal pain control system, which leads to neuroplasticity and d...
Novel applications of common stereology software to represent the complete dist...
Leite-Almeida, Hugo; Almeida, ArmandoIn a recent study we have adapted for the first time available software used in spatial neuronal organization studies to represent the complete fiber distribution of a brain projection [Leite-Almeida H, Valle-Fernandes A, Almeida A. Brain projections from the medullary dorsal reticular nucleus: an anterograde and retrograde tracing study in the rat. Neuroscience 2006;140:577-95]. Here we describe the technique ...
A new model of laryngitis: neuropeptide, cyclooxygenase, and cytokine profile
Rodrigues, Manuel Lima; Fernandes, Ana Valle; Lamas, Nuno Jorge; Cruz, Andrea; Baltazar, Fátima; Milanezi, Fernanda; Nunes, Rui; Reis, R. M.Objectives/Hypothesis: To develop and characterize a new model of laryngeal inflammation by analyzing the presence of neurogenic peptides and expression of cyclooxygenases (COX) and cytokines in the mucosa.Study Design: Laryngitis induced by nasogastric intubation (NGI) was evaluated by histopathologic changes of the mucosa, alterations in calcitonin gene related peptide (CGRP) and substance P (SP) neuropeptide...
Gabapentin supplemented with ropivacain block of trigger points improves pain c...
Lemos, Laurinda; Flores, Sara; Oliveira, Pedro; Almeida, ArmandoObjective: Pain control in trigeminal neuralgia (TN) is achieved using anticonvulsivants, mainly carbamazepine. When this drug cannot be used, other drugs like gabapentin (GBP) have been used to provide adequate pain control. To improve the therapeutic effect of GBP, we evaluated the clinical efficacy of associating GBP with ropivacain (ROP) analgesic block of facial trigger points in TN patients. Design: Thirt...
Neuropathic pain is associated with depressive behaviour and induces neuroplast...
Gonçalves, Leonor; Silva, Rui Jorge; Ribeiro, Filipa Pinto; Pêgo, José M.; Bessa, J. M.; Pertovaara, Antti; Sousa, Nuno; Almeida, ArmandoChronic pain is associated with the development of affective disorders but the underlying mechanisms are not fully understood. Changes in brain centres implicated in both emotional and pain processing are likely to be critical in the interplay of pain control and affective emotional behaviour. In the present study, we assessed emotional behaviour and performed a structural analysis of the amygdala (AMY) in neur...
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